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RenovoRx Presenting Phase III Clinical Trial Interim Analysis Data of the TIGeR-PaC Study at American Association for Cancer Research Annual Meeting Underway in Orlando, Florida
Researchers Presenting Interim Data on Poster #CT084 Demonstrating RenovoGem™ Patients May Experience 60% Survival Benefit and 65% Side Effects Reduction
About this update from Renovorx, Inc.
[{"type":"text","content":"\nResearchers Presenting Interim Data on Poster #CT084 Demonstrating RenovoGem™ Patients May Experience 60% Survival Benefit and 65% Side Effects Reduction Versus Systemic Chemotherapy\n\n\n LOS ALTOS, Calif.--(BUSINESS WIRE)--\nRenovoRx, Inc. (“RenovoRx” or the “Company”) (Nasdaq: RNXT), a biopharmaceutical company focused on the localized treatment of solid tumors, announced that Poster #CT084 is presenting detailed, open label, Phase III TIGeR-PaC study interim data analysis of its innovative RenovoGem therapy for pancreatic cancer patients at the American Association for Cancer Research (AACR) Annual Meeting, on Monday, April 17, 2023, at 9:00 AM ET in Orlando, Florida. AACR is underway through Wednesday, April 19, 2023.\n\n\nThe interim analysis shows a 6-month median overall survival benefit for patients with locally advanced pancreatic cancer (“LAPC”) which is a 60% improvement over systemic chemotherapy, the current standard of care and study control arm (intravenous (IV) administration of gemcitabine and nab-paclitaxel). RenovoGem patients also demonstrated greater than 65% reduction in adverse events. These can include nausea, fatigue, and a decline in white blood cells.\n\n\nOn Monday, April 17, “Targeted Intra-arterial Gemcitabine vs. Continuation of IV Gemcitabine plus Nab-Paclitaxel following Induction with sequential IV Gemcitabine plus Nab-Paclitaxel and Radiotherapy for Unresectable Locally Advanced Pancreatic Cancer (TIGeR-PaC) – Phase III Trial Interim Analysis,” is being presented on Poster #CT084 by Michael Pishvaian, MD, Johns Hopkins Medicine Director of Gastrointestinal, Developmental Therapeutics and Clinical Research Programs, Amer H. Zureikat, MD, Professor of Surgery at the University of Pittsburgh School of Medicine, and other researchers.\n\n\nThis is the first interim analysis of the randomized multi-center Phase III open label TIGeR-PaC clinical trial, designed to investigate the Company’s first product candidate, RenovoGem. In this interim analysis, the control and treatment arms demonstrated divergence in median overall survival for patients. The study is designed to randomize 114 patients (57 in each arm) with all patients receiving upfront induction chemotherapy and stereotactic body radiation therapy (SBRT). The TIGeR-PaC Data Monitoring Committee (“DMC”) met and determined the interim data i...