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RenovoRx Highlights Recent Presentation of Clinical Data Abstract at the 2024 Society of Interventional Radiology Annual Scientific Meeting
Sub-study of the pivotal Phase III TIGeR-PaC clinical trial offers important data to potentially assist in optimization of TAMP therapy LOS ALTOS,
About this update from Renovorx, Inc.
[{"type":"text","content":"\nSub-study of the pivotal Phase III TIGeR-PaC clinical trial offers important data to potentially assist in optimization of TAMP therapy\n\n\n LOS ALTOS, Calif.--(BUSINESS WIRE)--\nRenovoRx, Inc. (“RenovoRx” or the “Company”) (Nasdaq: RNXT), a clinical-stage biopharmaceutical company developing novel precision oncology therapies based on a local drug-delivery platform, today highlights a presentation of a clinical data abstract at the recent 2024 Society of Interventional Radiology (SIR) Annual Scientific Meeting, held March 23-27, 2024 in Salt Lake City, Utah. Clinical data was presented by David Sperling, MD, Associate Professor of Radiology at Columbia University Irving Medical Center in New York.\n\n\nDr. Sperling, together with his co-authors, presented “Mesenteric Venous Thrombosis as a Predictor of Target Artery Thrombosis and Tran-Arterial Micro Perfusion Treatment Completion Among Patients with Locally Advanced Pancreatic Cancer (LAPC),” a sub-study of RenovoRx’s ongoing pivotal Phase III TIGeR-PaC clinical trial. In this sub-study, baseline abdominal CT imaging completed prior to randomization into the TIGeR-PaC study was reviewed for the presence or absence of Mesenteric Venous Thrombosis (MVT) by an independent core imaging radiologist. Outcomes examined 1) patient inability to complete the planned 8 treatments with RenovoRx’s patented Trans-Arterial Micro-Perfusion (TAMP™) therapy platform, 2) target vessel thrombosis during or after TAMP, and 3) side effects of pain or discomfort associated with the use of TAMP.\n\n\nPatients with pancreatic cancer are commonly at risk of both arterial and venous thromboembolism, obstructions of an artery or blood vessel by a blood clot, and MVT can also be an incidental finding when treating this important patient population. MVT is a blood clot impacting one or more of the major veins that drain blood from the intestine that may make certain treatments difficult.\n\n\nThe data presentation highlighted that of the 25 patients randomized to the TAMP therapy, 6 failed to complete all 8 planned procedures due to thrombosis of the targeted arterial artery. Among those 6 patients, the prevalence of MVT on the baseline abdominal CT imaging was 100%.\n\n\n“Our sub-study presents important data to assist in optimization of TAMP with better risk stratification of patients while improving ...