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Relay Therapeutics to Present Initial Clinical Data on RLY-2608 at AACR
Relay Therapeutics to host conference call following AACR presentation CAMBRIDGE, Mass., March 06, 2023 (GLOBE NEWSWIRE) -- Relay Therapeutics, Inc. (Nasdaq:
About this update from Relay Therapeutics, Inc.
[{"type":"text","content":"Relay Therapeutics to host conference call following AACR presentation\nCAMBRIDGE, Mass., March 06, 2023 (GLOBE NEWSWIRE) -- Relay Therapeutics, Inc. (Nasdaq: RLAY), a clinical-stage precision medicine company transforming the drug discovery process by combining leading-edge computational and experimental technologies, today announced that initial clinical data from the ReDiscover trial for RLY-2608 have been selected for presentation at the upcoming American Association for Cancer Research (AACR) Annual Meeting 2023, being held April 14-19, 2023. Following the presentation, Relay Therapeutics will host a conference call to discuss the data. The AACR website indicates that clinical trial abstract titles will be posted on March 14, 2023 at 4:30 pm E.T. and that clinical trial abstracts will be published on April 14, 2023 at 12:00 pm E.T. Conference Call Information Relay Therapeutics will host a conference call and live webcast, with further details available closer to the event. Registration and dial-in for the conference call may be accessed through Relay Therapeutics’ website under Events in the News & Events section through the following link: https://ir.relaytx.com/news-events/events-presentations. An archived replay of the webcast will be available following the event. The presentation from AACR will be available shortly after the session on the Relay Therapeutics website under Publications: https://relaytx.com/publications/. About RLY-2608 RLY-2608 is the lead program of multiple efforts to discover and develop mutant selective inhibitors of PI3Kα. PI3Kα is the most frequently mutated kinase in all cancers, with oncogenic mutations detected in about 13% of patients with solid tumors. Traditionally, the development of PI3Kα inhibitors has focused on the active, or orthosteric, site. The therapeutic index of orthosteric inhibitors is limited by the lack of clinically meaningful selectivity for mutant versus wild-type (WT) PI3Kα and off-isoform activity. Toxicity related to inhibition of WT PI3Kα and other PI3K isoforms results in sub-optimal inhibition of mutant PI3Kα with reductions in dose intensity and frequent discontinuation. The Dynamo™ platform enabled the discovery of RLY-2608, the first known allosteric, pan-mutant (H1047X, E542X and E545X), and isoform-selective PI3Kα inhibitor designed to overcome these limitation...