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Foundation Medicine and Relay Therapeutics Collaborate to Develop FoundationOne®CDx as a Companion Diagnostic for Relay’s Investigational FGFR2 Inhibitor, RLY-4008
CAMBRIDGE, Mass.--(BUSINESS WIRE)-- Today Foundation Medicine, Inc., a pioneer in molecular profiling for cancer, and Relay Therapeutics (Nasdaq: RLAY), a
About this update from Relay Therapeutics, Inc.
[{"type":"text","content":" CAMBRIDGE, Mass.--(BUSINESS WIRE)--\nToday Foundation Medicine, Inc., a pioneer in molecular profiling for cancer, and Relay Therapeutics (Nasdaq: RLAY), a clinical-stage precision medicine company transforming the drug discovery process by combining leading-edge computational and experimental technologies, announced a collaboration to develop FoundationOne®CDx as a companion diagnostic for RLY-4008, the company’s investigational FGFR2 inhibitor.\nThis press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20220912005297/en/\nRLY-4008 is a selective oral small molecule inhibitor of FGFR2, which is currently being evaluated for use in patients with FGFR2-mutated cholangiocarcinoma (CCA), or bile duct cancer, and other solid tumors. FGFR2 is one of four members of the FGFR family, a set of closely related proteins with highly similar protein sequences and properties. If the therapy and companion diagnostic are approved, FoundationOne CDx would be used to identify patients with FGFR2 fusions and select rearrangements in CCA who may be appropriate for treatment with RLY-4008.\n\nYesterday, at the European Society of Medical Oncology (ESMO) 2022 Congress, Relay presented interim clinical data for RLY-4008 from this patient population in pan-FGFR inhibitor naïve patients demonstrating an 88% overall response rate and anticipates fully enrolling this pivotal cohort in the second half of 2023.\n\n“FGFR2-mutated cholangiocarcinoma is an aggressive condition that’s generally diagnosed in advanced stages when prognosis is poor and treatment options are limited,” said Don Bergstrom, M.D., Ph.D., President of R&D at Relay Therapeutics. “We’re proud to partner with the leader in companion diagnostic approvals as we work to advance this potentially life-changing therapy and create access to it once approved.”\n\nFoundation Medicine’s portfolio of FDA-approved comprehensive genomic profiling tests offers physicians both blood- and tissue-based testing options for detecting genomic alterations that help guide personalized treatment decisions. As companion diagnostics, FoundationOne CDx and FoundationOne®Liquid CDx allow oncologists to identify patients who may be appropriate for FDA-approved targeted therapies.\n\n“Relay Therapeutics is an innovator in precision therapy development who shares our c...