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Rapport Therapeutics Announces New Data and Post Hoc Analysis Demonstrating the Magnitude and Consistency of RAP-219’s Clinical Response in Patients with Focal Onset Seizures
Post-hoc analysis of RAP-219 Phase 2a data showed early onset of action and consistency of median response over the entire treatment period, along with
About this update from Rapport Therapeutics, Inc.
[{"type":"text","content":"Post-hoc analysis of RAP-219 Phase 2a data showed early onset of action and consistency of median response over the entire treatment period, along with consistent efficacy data regardless of patients’ disease severity RAP-219 demonstrated meaningful improvements in patient-reported seizure severity among those with moderate or greater baseline impairment BOSTON and SAN DIEGO, Dec. 05, 2025 (GLOBE NEWSWIRE) -- Rapport Therapeutics, Inc. (Nasdaq: RAPP) (Rapport or the Company), a clinical-stage biotechnology company dedicated to the discovery and development of small molecule precision medicines for patients with neurological or psychiatric disorders, today announced new data and post hoc analysis on clinical and patient reported benefits of RAP-219 in drug-resistant focal onset seizures (FOS), alongside topline efficacy and safety data from its recently reported Phase 2a FOS trial. The results were presented at the 2025 American Epilepsy Society (AES) Annual Meeting and include RAP-219’s early treatment effects and consistent median efficacy data across the full treatment period, its performance across varying levels of baseline disease severity, and its impact on seizure severity. “These additional results build upon the robust efficacy data we observed in the Phase 2a trial and further expand the growing body of evidence supporting RAP-219’s potential as a best-in-class anti-seizure medication for patients with drug-resistant focal onset seizures,” said Jeffrey Sevigny, M.D., chief medical officer of Rapport. “Our analysis showed that RAP-219 demonstrated strong clinical response - early in treatment, consistent over time, and across the spectrum of disease severity. Additionally, RAP-219 substantially reduced the impact of seizures on patients’ daily functioning, reinforcing its potential to make a meaningful difference in the lives of patients with epilepsy. With these results, we believe we are well positioned to advance into registrational trials, as we continue the development of RAP-219 as a potential therapy for people living with epilepsy.” The Company plans to hold an end-of-Phase 2 meeting with the U.S. Food and Drug Administration this quarter and anticipates initiating two pivotal Phase 3 trials of RAP-219 using traditional clinical seizure endpoints in the third quarter of 2026. Rapport announced topline results fr...