Business
Homology Medicines Reports First Quarter 2023 Financial Results and Recent Highlights
- On Track to Report Initial Clinical Data from pheEDIT PKU Gene Editing Trial Mid-Year 2023 - - First Presentations of Preclinical Data with GTx-mAb
About this update from Q32 Bio Inc.
[{"type":"text","content":"- On Track to Report Initial Clinical Data from pheEDIT PKU Gene Editing Trial Mid-Year 2023 - - First Presentations of Preclinical Data with GTx-mAb Development Candidate HMI-104 for PNH, and Potential for Re-Dosing with AAVHSCs, at Upcoming ASGCT Meeting - - Solid Financial Position with Anticipated Cash Runway into Fourth Quarter 2024 - BEDFORD, Mass., May 11, 2023 (GLOBE NEWSWIRE) -- Homology Medicines, Inc. (Nasdaq: FIXX), a genetic medicines company, announced today financial results for the first quarter ended March 31, 2023, and highlighted recent accomplishments. “We look forward to announcing the first gene editing data in people with PKU, as we are on track to report initial clinical data mid-year 2023 from our pheEDIT trial evaluating HMI-103,” said Albert Seymour, Ph.D., President and Chief Executive Officer of Homology Medicines. “I am pleased to share that the second participant was dosed in the pheEDIT trial, a third participant is in screening and there continues to be strong interest from the patient and physician community in this one-time gene editing approach for PKU.” Continued Dr. Seymour, “We will have a big presence at ASGCT next week with presentations spanning our genetic medicines platform, including new preclinical data with the anti-C5 GTx-mAb development candidate, HMI-104 for PNH, which demonstrated sustained expression of functional C5 monoclonal antibody levels in multiple in vivo models. We will also present the first preclinical data sets demonstrating the potential to re-dose with AAVHSCs, as well as methods to identify genomic sites with improved gene editing integration, which highlight our commitment to scientific innovation in gene editing and gene therapy.” First Quarter 2023 and Recent Accomplishments Announced that the second participant has been dosed in the Phase 1 pheEDIT clinical trial evaluating in vivo nuclease-free gene editing candidate HMI-103 in adults with phenylketonuria (PKU), and a third participant is advancing through screening to complete the first dose cohort of the trial. Homology continues to expect initial clinical data from the trial mid-year 2023.Continued recruitment efforts for the Phase 1 juMPStart trial evaluating in vivo HMI-203 gene therapy candidate in adults with Hunter syndrome (MPS II).Progressed HMI-104, a C5 monoclonal antibody development candidate f...