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Brain Lymphatics Programme Published in Nature
Brain Lymphatics Programme Published in Nature.
About this update from Puretech Health Plc
[{"type":"text","content":"\n \nRNS Number : 7983V PureTech Health PLC 26 July 2018 \n\n26 July 2018\nPureTech Health plc\n \nPureTech Health Collaborator Publishes in Journal Nature Regarding New Insights into Key Role of Brain Lymphatics in Alzheimer's and Other Neurodegenerative Diseases\n \nRelated intellectual property exclusively licensed to PureTech Health and being advanced as part of growing internal research and development division\n \nPureTech Health plc (LSE: PRTC) (\"PureTech Health\"), a clinical-stage biopharmaceutical company developing novel medicines for dysfunctions of the Brain-Immune-Gut (BIG), today notes the publication of foundational science in Nature which underlies its new internal programme focused on treating central nervous system (CNS) disorders via modulation of the brain's lymphatic system.\n \nThe approach is based on the work of Jonathan Kipnis, PhD, Harrison Distinguished Teaching Professor and Chair, Department of Neuroscience, and Director, Centre for Brain Immunology and Glia, at the University of Virginia School of Medicine. In 2015, Dr Kipnis published his original discovery of lymphatic vessels in the brain in Nature. Building on that discovery, Dr Kipnis' latest publication reveals the potential role of these lymphatic vessels, including in Alzheimer's disease, Huntington's disease, and age-associated cognitive decline. The publication presents preclinical models that suggest modulation of lymphatic function in the brain may prevent or delay diseases associated with aging.\n \n\"Dr Kipnis' original work completely changed the way we view immune privilege in the brain - the unique biological properties that protect certain areas of the body from inflammatory immune responses,\" said Joseph Bolen, PhD, Chief Scientific Officer at PureTech Health. \"This new discovery once again offers novel insights into the lymphatics' role in maintaining brain homeostasis and suggests that neurodegeneration may be tied to drainage issues in the brain. Because neurodegeneration is associated with so many devastating conditions, these findings provide us with a unique opportunity to develop treatments that address one of the world's highest global disease burdens.\"\n \nPureTech Health has exclusively licensed this intellectual property from the University of Virginia (UVA) Licensing &...