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New Data Shows CK1d Blocks Tau in AD Model
New Data Shows CK1d Blocks Tau in AD Model.
About this update from Proteome Sciences Plc
[{"type":"text","content":"\n \nRNS Number : 5620J Proteome Sciences PLC 18 July 2013 \n \n\nProteome Sciences plc\n \nNew Data Shows CK1d Blocks Tau in AD Model\n \n18th July 2013, Cobham, UK: Proteome Sciences yesterday made two poster presentations showing new data and results from its novel casein kinase 1 delta (CK1d) inhibitor program in Alzheimer's disease. The results show that the two lead compounds are orally available, attain therapeutic levels in the brain of experimental Alzheimer's models and improve cognitive behaviour. When the tau protein of treated animals was analysed a decrease was seen at key sites in total tau deposition and in tau phosphorylation. Treatment also caused a dramatic drop in the amount of the target protein in the brain. Taken together these data show that inhibition of CK1d acts through multiple mechanisms to reduce the amount of pathological tau protein which is increasingly recognised as a major goal for effective Alzheimer's disease treatments.\n \nCommenting on the results, Dr. Ian Pike, COO of Proteome Sciences plc and presenting author of the posters said:\n \n\"Having our posters selected for presentation at AAIC reflects the recognition and potential of our CK1d inhibitor program for treating Alzheimer's disease and other tauopathies. The latest results provide a strong mechanistic basis for the improved cognition seen in treated animals. As the pharmaceutical industry is increasing the search for new targets beyond beta-amyloid our ability to reduce tau pathology is very timely and will enhance our ongoing discussions to outlicense our CK1d program to the right pharmaceutical partner.\"\n \n- Ends -\n \nFor further information please contact:\n\n\n\n\nProteome Sciences plc\n\n\n\n\n\n\n\nChristopher Pearce, Chief Executive Officer\n\n\nTel: +44 (0)1932 865065\n\n\n\n\nDr. Ian Pike, Chief Operating Officer\nJames Malthouse, Finance Director\n\n\n\n\n\n\n\n\n\n\n\n\nNominated Adviser\n\n\n\n\n\n\n\nCenkos\n\n\n\n\n\n\n\nStephen Keys/Camilla Hume\n\n\nTel: +44 (0)20 7397 8900\n\n\n\n\n\n\n\n\n\n\n\n\nPublic Relations\n\n\n\n\n\n\n\nIKON Associates \n\n\n\n\n\n\n\nAdrian Shaw \n\n\n\n\n\n\n\nTel: +44 (0)1483 271291\n\n\n\n\n\n\n\n \nNotes to Editors:\nAbout Proteome Sciences\nProteome Sciences is a global leader in applied prot...