Clinical Response and Durability of Response of Rusfertide (PTG-300) in Polycythemia Vera Featured Today at EHA Press Briefing; Protagonist Therapeutics Plans a Follow-on Two-Year Extension Study to Enable Further Evaluation of the Long-Term Effects o...

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[{"type":"text","content":"Clinical Response and Durability of Response of Rusfertide (PTG-300) in Polycythemia Vera Featured Today at EHA Press Briefing; Protagonist Therapeutics Plans a Follow-on Two-Year Extension Study to Enable Further Evaluation of the Long-Term Effects of Rusfertide in PV \n NEWARK, CA / ACCESSWIRE / June 9, 2023 / Protagonist Therapeutics, Inc. (NASDAQ:PTGX) (\"Protagonist\" or \"the Company\") announced today that Ronald Hoffman, MD, Icahn School of Medicine at Mount Sinai, provided a press briefing this morning on the late-breaking oral presentation abstract LB2710: Targeted Therapy of Uncontrolled Erythrocytosis in Polycythemia Vera with the Hepcidin Mimetic, Rusfertide - Blinded Randomized Withdrawal Results of the REVIVE Study at the European Hematology Association (EHA) 2023 Congress. The study results will be presented in detail by Marina Kremyanskaya, MD, PhD, Icahn School of Medicine at Mount Sinai, on Sunday, June 11, 2023 at 9:45-10:00 CEST.\"The positive outcomes of the REVIVE study showcase the efficacy and tolerability of rusfertide as a highly effective therapy for uncontrolled erythrocytosis and associated symptoms in PV, and represent a significant advancement in the treatment of this malignant myeloproliferative neoplasm,\" said Dr. Hoffman. \"Rusfertide offers a novel hormone mimetic-based approach which acts by selectively targeting uncontrolled erythrocytosis, providing sustained and durable hematocrit control and potentially improving PV-related symptoms and quality of life in these patients.\"Based on these and other previously announced data from the Phase 2 REVIVE Study of rusfertide (PTG-300) in polycythemia vera, which showed patients on rusfertide remain largely phlebotomy free with durable hematocrit control under 45%, the company is planning a follow-on two year extension study, PTG-300-21, for patients who complete the current three-year Phase 2 (REVIVE) study, thereby enabling evaluation of the effects of rusfertide in PV for up to five years.\"As previously announced, data from the randomized withdrawal portion of the Phase 2 REVIVE study showed that nearly 70% of subjects receiving rusfertide treatment met the definition of clinical responders (p=0.0003) and more than than 92% of subjects in the rusfertide arm remained phlebotomy free. These are patients who would have otherwise required frequent ...

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