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Propanc Biopharma Appoints Belen Toledo to Evaluate Impact of Proenzyme Therapy on Tumor Microenvironment
MELBOURNE, Australia--(BUSINESS WIRE)-- Propanc Biopharma, Inc. (OTCQB: PPCB) (“Propanc” or the “Company”), a biopharmaceutical company developing novel
About this update from Propanc Biopharma, Inc.
[{"type":"text","content":" MELBOURNE, Australia--(BUSINESS WIRE)--\nPropanc Biopharma, Inc. (OTCQB: PPCB) (“Propanc” or the “Company”), a biopharmaceutical company developing novel cancer treatments for patients suffering from recurring and metastatic cancer, announced today that the Company appointed Ms. Belen Toledo MSc., a biotechnologist specializing in cell regenerative medicine, to evaluate the impact of proenzyme therapy on the tumor microenvironment. Ms. Toledo’s work will be part of the Proenzymes Optimization Project 1 (“POP1”) Joint Research and Drug Discovery Program designed to produce synthetic recombinant, commercial scale quantities of the two proenzymes trypsinogen and chymotrypsinogen.\n\nMs. Toledo, will elucidate molecular pathways involved in the proenzymes anti-tumor efficacy and study how they interact with the pre-metastatic tumor niche, focusing on the interaction and suppression of tumor associated cells, like cancer-associated fibroblasts and macrophages. A pre-metastatic tumor niche is an environment in a secondary organ conducive to the metastasis (spreading) of a primary tumor. Such a niche provides favorable conditions for growth, and eventually metastasis, in an otherwise foreign and hostile environment for the primary tumor cells. Metastasis remains the main cause of patient death from solid tumors for cancer sufferers. To achieve this, Ms. Toledo will use integrated tumor models in a microfluidics chip by obtaining 3-dimensional bio-impressions of tumor cells from patients with advanced solid tumors, developed at the Centre for Biomedical Research, University of Granada, Granada, Spain, led by Prof. Juan Marchal M.D.\n\n“Belen Toledo is a very capable biotechnologist who is excited about the project and its potential as a novel approach for the prevention and treatment of metastatic cancer. We look forward to exploring the potential of proenzyme therapy, which is groundbreaking research,” said Prof. Macarena Perán, Ph.D., Lecturer and Joint Research Supervisor from Jaén University.\n\n“The application of 3D tumor models on-a-chip will allow us to faithfully recreate tumor heterogeneity and stroma-tumor interactions. We aim to evaluate the effect of proenzyme therapy on effective personalized therapy models, generated from a small biopsy of patients,” said Prof. Juan Antonio Marchal M.D., Joint Research Supervisor from Gr...