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Lead Therapeutic Candidate, PMN310, Demonstrates Enhanced Selectivity for Toxic Oligomers Compared to Other Amyloid-Beta-Directed Antibodies in Poster Presentation at AD/PD 2023
PMN310 demonstrated greater selectivity for target toxic oligomers over monomers compared to other amyloid-beta-directed antibodies. Greater selectivity of
About this update from Promis Neurosciences Inc.
[{"type":"text","content":"PMN310 demonstrated greater selectivity for target toxic oligomers over monomers compared to other amyloid-beta-directed antibodies. Greater selectivity of PMN310 for toxic oligomers indicates a potentially differentiated profile and supports further development\nTORONTO, Ontario and CAMBRIDGE, Massachusetts, March 29, 2023 (GLOBE NEWSWIRE) -- ProMIS Neurosciences Inc. (TSX: PMN) (Nasdaq: PMN), a biotechnology company focused on the generation and development of antibody therapeutics targeting toxic misfolded proteins in neurodegenerative diseases such as Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS) and multiple system atrophy (MSA), today presented new in vitro preclinical data supporting the differentiation of PMN310 from other amyloid-beta (Aβ)-directed antibodies at the International Conference on Alzheimer’s and Parkinson’s Disease and Related Neurological Disorders (AD/PD 2023). Antibody therapies that target Aβ in AD continue to generate interest with recent approvals and new potential treatments in development. A large body of evidence suggests that soluble toxic Aβ oligomers, rather than Aβ monomers or plaque, are the principal driver of synaptic dysfunction, neuronal loss and cognitive decline in AD patients. However, it has been a challenge to specifically target toxic oligomers since they are the least abundant form of Aβ in the brain. In preclinical studies, ProMIS Neurosciences’ lead candidate, PMN310, has demonstrated its ability to selectively target pathogenic Aβ oligomers without unproductive binding to non-toxic monomers or plaque. “We believe these encouraging data help differentiate our lead therapeutic candidate, PMN310, from other Aβ-directed antibodies. As shown in our AD/PD poster, PMN310 selectively targeted toxic oligomers and avoided interaction with plaque and vascular deposits,” said Johanne Kaplan, Ph.D., Chief Development Officer of ProMIS Neurosciences. “We believe that these data support clinical development of PMN310, and we are excited to submit an IND application in the coming weeks as we advance our plans to bring a next-generation therapy to patients suffering with Alzheimer’s disease.” Dr. Kaplan will be interviewed by VJNeurology during the AD/PD meeting. Links will be posted to the Events page of the ProMIS website once available. In a poster presentation titled, “Differ...