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Precigen Achieves Significant Clinical Progress for UltraCAR-T® and AdenoVerse™ Therapies
- 50% (3 out of 6) objective response rate (ORR) in relapsed or refractory (r/r) acute myeloid leukemia (AML) patients treated with PRGN-3006 at the two
About this update from Precigen, Inc.
[{"type":"text","content":"- 50% (3 out of 6) objective response rate (ORR) in relapsed or refractory (r/r) acute myeloid leukemia (AML) patients treated with PRGN-3006 at the two lowest dose levels (a single administration of 4 to 28 million UltraCAR-T cells) in the lymphodepletion cohort of the ongoing Phase 1 trial -\n - 40% ORR (2 out of 5) and 60% disease control rate (DCR) (3 out of 5) in recurrent or metastatic human papilloma virus (HPV)-associated cancer patients treated in the PRGN-2009 combination arm of the ongoing Phase 1 trial -\n - Preliminary PRGN-2012 Phase 1 data show encouraging clinical activity, including ongoing reduction/elimination of the need for surgical intervention at the most recent follow-up, up to 12 weeks after PRGN-2012 treatment -\n - PRGN-3005 and PRGN-3006 UltraCAR-T demonstrate favorable safety profiles with no dose-limiting toxicities or neurotoxicity, dose-dependent in vivo expansion and durable persistence -\n - PRGN-2009 and PRGN-2012 AdenoVerse immunotherapies demonstrate favorable safety profiles with no dose-limiting toxicities, strong antigen-specific immune response and lack of significant neutralizing antibody response upon repeat administrations -\n - PRGN-3006 clinical abstract (Abstract# 825) selected for oral presentation at the 63rd American Society of Hematology (ASH) Annual Meeting and Exposition -\n - Precigen to host 2021 R&D Day virtual event today at 11:00 AM ET -\n\n\nGERMANTOWN, Md., Nov. 4, 2021 /PRNewswire/ -- Precigen, Inc. (Nasdaq: PGEN), a biopharmaceutical company specializing in the development of innovative gene and cell therapies to improve the lives of patients, announced a topline summary of the presentations planned for today's 2021 R&D Day virtual event, which begins at 11:00 AM ET. Participants may register and access the live webcast through Precigen's investor relations website in the Events & Presentations section.\n\n \n \n \n \n \n \n\n \nToday's event will showcase clinical progress for Precigen's UltraCAR-T platform, including PRGN-3005 UltraCAR-T, PRGN-3006 UltraCAR-T, PRGN-3007 UltraCAR-T and the AdenoVerse immunotherapy platform, including PRGN-2009 off-the-shelf (OTS) AdenoVerse Immunotherapy, and PRGN-2012 OTS AdenoVerse Immunotherapy. Presentations will be made by Precigen executives and clinical trial investigators, including:\nHelen Sabzevari, PhD, President and CEO o...