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Plus Therapeutics Announces Presentation of ReSPECT-GBM Trial Dosimetery Data at the American Society for Radiation Oncology (ASTRO) 2021 Annual Meeting
Data demonstrated Rhenium-186 NanoLiposome (186RNL) provides sustained, localized radiation treatment for over eight days to the tumor with minimal whole
About this update from Plus Therapeutics, Inc.
[{"type":"text","content":"Data demonstrated Rhenium-186 NanoLiposome (186RNL) provides sustained, localized radiation treatment for over eight days to the tumor with minimal whole brain and body radiation exposure The analysis of 3D drug distribution and tumor response shows image monitoring is a predictive tool to evaluate delivery and treatment effectiveness Compared to sealed source brachytherapy, 186RNL offers minimally invasive, convenient delivery AUSTIN, Texas, Oct. 27, 2021 (GLOBE NEWSWIRE) -- Plus Therapeutics, Inc. (Nasdaq: PSTV) (the “Company”), a clinical-stage pharmaceutical company developing innovative, targeted radiotherapeutics for rare and difficult-to-treat cancers, today presented data at the American Society for Radiation Oncology (ASTRO) 2021 Annual Meeting indicating Rhenium-186 NanoLiposome (186RNL) delivered to patients with recurrent glioblastoma (GBM) through convection enhanced delivery results in predictable distribution and stable retention to the targeted tissues, providing days of sustained, localized radiation treatment to the tumor. Data from the ePoster titled “Image-guided Rhenium-186 NanoLiposome (186RNL) brachytherapy in the treatment of recurrent glioblastoma: technique, image analysis, dosimetry, and monitoring” demonstrated the following: Mean locoregional retention in the brain volume at the end of infusion (85.9% ± 17.1% ID, n=18) and at eight days post-infusion (46.6% ± 16.7% ID, n=17).Following dose escalation, the mean radiation absorbed dose in the two most recent cohorts to the tumor volume was 354.7 ± 144.0 Gy, to the whole brain was 1.32 ± 1.06 Gy, and to the whole body was 0.16 ± 0.04 Gy (n=6), establishing evidence of a high radiation absorbed dose to the tumor with minimal brain and whole body radiation exposure. “We’re very encouraged by this latest data supporting investigational 186RNL for the treatment of recurrent glioblastoma, specifically underscoring its potential to effectively treat difficult to reach brain tumors, without harming surrounding tissue,” said John Floyd, M.D., University of Texas Health Science Center San Antonio, study investigator, and presenter of the ePoster. “Coupled with state-of-the-art imaging technology tools, treatment with 186RNL has shown to be highly precise, which may give reassurance to patients living with recurrent glioblastoma and advance understanding of conve...