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Pliant Therapeutics Presents Data from its Bexotegrast Program at the European Association for the Study of the Liver (EASL) International Liver Congress™
Presentations highlight preclinical and clinical advancements of bexotegrast program in primary sclerosing cholangitis SOUTH SAN FRANCISCO, Calif., June 23,
About this update from Pliant Therapeutics, Inc.
[{"type":"text","content":"Presentations highlight preclinical and clinical advancements of bexotegrast program in primary sclerosing cholangitis\nSOUTH SAN FRANCISCO, Calif., June 23, 2023 (GLOBE NEWSWIRE) -- Pliant Therapeutics, Inc. (Nasdaq: PLRX), a clinical stage biotechnology company focused on discovering and developing novel therapeutics for the treatment of fibrosis, today announced that it presented Phase 2a clinical data and preclinical data of bexotegrast (PLN-74809) program this week as part of the European Association for the Study of the Liver (EASL) International Liver Congress™ 2023, held June 21- 24, 2023. Bexotegrast, is an oral, small molecule, dual-selective inhibitor of αvβ6 and αvβ1 integrins being developed for the treatment of idiopathic pulmonary fibrosis and primary sclerosing cholangitis (PSC). “PSC is a rare chronic autoimmune disease with no effective therapy, representing a large unmet need for new treatments. Our presentations this week discuss the early non-clinical work that support our ongoing Phase 2a clinical program. We look forward to sharing interim data from this trial in the third quarter,” said Éric Lefebvre, M.D., Chief Medical Officer at Pliant Therapeutics. INTEGRIS-PSC Phase 2a Study: Evaluating the Safety, Tolerability, and Pharmacokinetics of Bexotegrast (PLN-74809) in Participants with Primary Sclerosing Cholangitis The study design, baseline demographics and blinded safety data from the 85 participants randomized into the 40, 80 and 160 mg dose cohorts or placebo was presented from the ongoing INTEGRIS-PSC Phase 2a study. This study is evaluating the safety, tolerability, and pharmacokinetics of bexotegrast in PSC. Twelve-week data from this study is expected in the third quarter of 2023. Following a positive independent Data Safety Monitoring Board (DSMB) safety review in the first quarter, enrollment commenced in a Phase 2a trial of bexotegrast at 320 mg dosed once daily for at least 24 weeks, and up to 48 weeks, in patients with PSC. The following posters were selected for inclusion in EASL’s Session Poster Tours. Dual alpha-v/beta-6 and alpha-v/beta-1 Integrin Inhibitor Bexotegrast Attenuates Profibrogenic Gene Expression of Myofibroblasts in Human Liver Explant Tissue with Biliary Fibrosis The effects of bexotegrast on individual cell populations were evaluated in fibrotic PSC and primary biliary cho...