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Pliant Therapeutics Presentations at The Liver Meeting® 2023 Highlight Bexotegrast, an Inhibitor of αvß6 and αvß1 Integrins, in Primary Sclerosing Cholangitis
INTEGRIS-PSC interim results highlighted in an oral late-breaker presentation SOUTH SAN FRANCISCO, Calif., Nov. 13, 2023 (GLOBE NEWSWIRE) -- Pliant
About this update from Pliant Therapeutics, Inc.
[{"type":"text","content":"INTEGRIS-PSC interim results highlighted in an oral late-breaker presentation\nSOUTH SAN FRANCISCO, Calif., Nov. 13, 2023 (GLOBE NEWSWIRE) -- Pliant Therapeutics, Inc. (Nasdaq: PLRX), a clinical-stage biotechnology company and leader in the discovery and development of novel therapeutics for the treatment of fibrotic diseases, today announced the presentation of preclinical data and clinical data from the INTEGRIS-PSC Phase 2a trial of bexotegrast in patients with primary sclerosing cholangitis (PSC). These posters were presented at The Liver Meeting® 2023 of the American Association for the Study of Liver Diseases (AASLD). The meeting is being held November 10-14, 2023. “Our presentations at the Liver Meeting feature preclinical and clinical work supportive of bexotegrast’s antifibrotic mechanism of action in liver fibrosis,” said Éric Lefebvre, M.D., Chief Medical Officer of Pliant. “A highlight of the conference was the late-breaker presentation of our recent positive interim data from the INTEGRIS-PSC trial, demonstrating the potential of bexotegrast in the unmet area of need of patients with PSC.” Late Breaker: Oral αvβ6/αVβ1 Integrin Inhibition in Primary Sclerosing Cholangitis: 12-week Interim Safety and Efficacy Analysis of INTEGRIS-PSC, A Phase 2a Trial of Bexotegrast Professor Gideon Hirschfield, M.D., Lily and Terry Horner Chair in Autoimmune Liver Disease Research, Toronto Centre for Liver Disease and INTEGRIS-PSC trial investigator presented interim data from the 40, 80, 160 mg dose cohorts from INTEGRIS-PSC, an ongoing, double-blind, dose-ranging, randomized, placebo-controlled Phase 2a trial of bexotegrast in participants with PSC. Bexotegrast was well tolerated over 12 weeks of treatment with no treatment-related severe or serious treatment emergent adverse events. At all doses tested, bexotegrast reduced changes in enhanced liver fibrosis (ELF) score and PRO-C3 levels from Baseline relative to placebo, with statistically significant differences for both parameters observed with the 160 mg dose. Twelve-week data from the INTEGRIS-PSC 320mg cohort is expected in the first quarter of 2024. Inhibition of Integrin αVβ1 Attenuates Profibrogenic Gene Expression by Myofibroblasts in Fibrotic Human Liver Explants An αVβ1-selective integrin inhibitor was evaluated on fibrotic and non-fibrotic human liver tissue to assess ...