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Pliant Therapeutics INTEGRIS-PSC Phase 2a Data Evaluating Bexotegrast in Primary Sclerosing Cholangitis to be Highlighted in a Late-Breaking Presentation at The Liver Meeting® 2024
INTEGRIS-PSC to be featured in an oral presentation on Monday, November 18 SOUTH SAN FRANCISCO, Calif., Oct. 17, 2024 (GLOBE NEWSWIRE) -- Pliant Therapeutics,
About this update from Pliant Therapeutics, Inc.
[{"type":"text","content":"INTEGRIS-PSC to be featured in an oral presentation on Monday, November 18 SOUTH SAN FRANCISCO, Calif., Oct. 17, 2024 (GLOBE NEWSWIRE) -- Pliant Therapeutics, Inc. (Nasdaq: PLRX), a late-stage biotechnology company and leader in the discovery and development of novel therapeutics for the treatment of fibrotic diseases, today announced a late-breaking presentation of results from the INTEGRIS-PSC Phase 2a trial of bexotegrast in patients with primary sclerosing cholangitis (PSC) at The Liver Meeting® 2024 of the American Association for the Study of Liver Diseases (AASLD), in San Diego, California November 15 – 19. Bexotegrast is an oral, small molecule, dual selective inhibitor of αvß6 and αvß1 integrins that is being studied for the treatment of idiopathic pulmonary fibrosis (IPF) and PSC. The oral presentation titled “Bexotegrast, an oral inhibitor of αvβ6 and αvβ1 integrins, was shown to improve markers and symptoms of cholestasis and stabilized markers of liver fibrosis in participants with primary sclerosing cholangitis: Week 24 results from the Phase 2 INTEGRIS-PSC trial,” will be delivered by Kris Kowdley M.D., AGAF, FAASLD, FACP, FACG, Director, Liver Institute Northwest and Professor of Medicine, Elson S. Floyd College of Medicine at Washington State University. Late-Breaking Oral Presentation Title: Bexotegrast, an oral inhibitor of αvβ6 and αvβ1 integrins, was shown to improve markers and symptoms of cholestasis and stabilized markers of liver fibrosis in participants with primary sclerosing cholangitis: Week 24 results from the Phase 2 INTEGRIS-PSC trialPresenter: Kris Kowdley, M.D.Session: Late Breaking Abstract Parallel Session 1Session Time: November 18, 2024, 2:00 p.m. - 3:30 p.m. PSTPresentation Time: November 18, 2024, 3:00 p.m. - 3:15 p.m. PSTPublication Number: 5004 The late breaker poster will be made available on the Publications page of the Pliant website at the time of presentation. Background on Primary Sclerosing Cholangitis PSC is a rare, progressive liver disease of unknown origin, which frequently occurs in the setting of inflammatory bowel disease. PSC affects more than 30,000 patients in the United States and over 100,000 patients worldwide. The disease can occur in all ages, genders, and races. PSC is characterized by inflammation and fibrosis, with progressive liver and biliary damage leading to ...