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Pliant Therapeutics Announces Presentations at 2022 American Thoracic Society International Conference
SOUTH SAN FRANCISCO, Calif., May 18, 2022 (GLOBE NEWSWIRE) -- Pliant Therapeutics, Inc. (Nasdaq: PLRX), a clinical stage biotechnology company focused on
About this update from Pliant Therapeutics, Inc.
[{"type":"text","content":"SOUTH SAN FRANCISCO, Calif., May 18, 2022 (GLOBE NEWSWIRE) -- Pliant Therapeutics, Inc. (Nasdaq: PLRX), a clinical stage biotechnology company focused on discovering and developing novel therapeutics for the treatment of fibrosis, today announced that the Company presented five scientific posters as part of the 2022 American Thoracic Society (ATS) International Conference held May 13-18, 2022, in San Francisco, California. Éric Lefebvre, M.D., Chief Medical Officer at Pliant Therapeutics commented: “We are very pleased with the breadth of our oral and poster presentations at this year's ATS meeting, which reflect some of the data aimed at derisking the development of PLN-74809 as the potential new treatments for IPF.” Pliant presented the following posters as part of the 2022 ATS International Conference. Poster 419: PLN-74809, A Dual-Selective Inhibitor of αvβ6and αvβ1, Is Well Tolerated in Over 280 Healthy Participants Results from an analysis of the seven completed Phase 1 studies with available safety data as of October 1, 2021, showed that PLN-74809 was generally well tolerated in 283 healthy participants receiving single doses up to 640 mg or multiple doses up to 320 mg once daily, administered for up to 14 days. The most frequently reported adverse events were headache and constipation, and no drug-related severe adverse events were reported. To date, PLN-74809 has been administered to over 450 subjects, including healthy participants as well as those with idiopathic pulmonary fibrosis (IPF), primary sclerosing cholangitis (PSC), or acute respiratory distress syndrome (ARDS) without any new safety concerns. Poster 710 PLN-74809, a Dual-Selective Inhibitor of Integrins αvβ6 and αvβ1, Shows Dose-Dependent Target Engagement in the Lungs of Patients with Idiopathic Pulmonary Fibrosis (IPF) Interim results from the ongoing Phase 2a αvβ6 positron emission tomography (PET) imaging trial in patients with IPF showed dose- and plasma concentration-dependent target engagement with all participants achieving >50% αvβ6 target engagement. In two participants, αvβ6 target engagement approached saturation (>90%) at the two highest doses of 240 mg and 320 mg. No severe or serious adverse events were reported. Poster 707: PLN-74809, an Oral, Dual-Selective αvβ6/αvβ1 Inhibitor in Phase 2 Clinical Trials for Idiopathic Pulmonary Fibrosis (IP...