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Pharvaris to Present PHVS416 and PHVS719 Clinical Data for Treatment of HAE at the ACAAI Annual Scientific Meeting 2022
ZUG, Switzerland, Nov. 10, 2022 (GLOBE NEWSWIRE) -- Pharvaris (Nasdaq: PHVS), a clinical-stage company developing novel, oral bradykinin-B2-receptor
About this update from Pharvaris N.v.
[{"type":"text","content":"ZUG, Switzerland, Nov. 10, 2022 (GLOBE NEWSWIRE) -- Pharvaris (Nasdaq: PHVS), a clinical-stage company developing novel, oral bradykinin-B2-receptor antagonists to treat and prevent hereditary angioedema (HAE) attacks, today announced it will be presenting two in-person “ePoster – Meet the Author” presentations at the American College of Allergy, Asthma & Immunology (ACAAI) Annual Scientific Meeting 2022, being held from November 10-14, 2022, in Louisville, Ky. “The data presented at ACAAI demonstrate the optimized pharmacokinetic and tolerability profiles of Pharvaris’ drug candidates that are in clinical development for the treatment of HAE,” said Peng Lu, M.D., Ph.D., Chief Medical Officer of Pharvaris. “PHVS719 is designed to be a once-daily prophylactic treatment for the prevention of HAE attacks, as supported by data demonstrating compound absorption in the colon and maintained exposure above predicted therapeutic levels. The cross-over pharmacokinetic data described in the second poster support the dosing regimen in CHAPTER-1, a Phase 2 study evaluating PHVS416 as a proof of concept of PHVS719 for the prophylactic treatment of HAE.” Presentation details and key data highlights include: Title: Development of PHVS719: an Oral Extended-Release Bradykinin B2 Receptor Antagonist to Prevent Hereditary Angioedema AttacksPresentation ID: P064Date and Time: Saturday, November 12, 2022, 12:05 p.m. ESTLocation: Exhibition Hall (Upper Concourse), Monitor 10 Pharmacokinetic properties of PHA121 were evaluated to support the intended therapeutic use of PHVS719 for the prophylactic treatment of HAE attacks using preclinical and clinical experimental models. Colonic absorption of PHA121 was investigated as a requisite for prolonged absorption of the extended-release formulation under development. In rodents, plasma concentrations following oral and intracolonic administrations of PHA121 were comparable, providing evidence that PHA121 can be systemically absorbed by colonic mucosa. In humans, high oral bioavailability and low fecal excretion further indicate almost-complete absorption in the gastrointestinal tract. Together, these data support clinical development of the extended-release tablet PHVS719 as a once-daily prophylactic treatment of HAE attacks. Title: Pharmacokinetics of PHVS719, extended-release tablet formulation of PHA121, ...