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Deucrictibant Data Highlighted in Multiple Presentations at the C1-Inhibitor Deficiency and Angioedema Workshop
ZUG, Switzerland, May 06, 2023 (GLOBE NEWSWIRE) -- Pharvaris (Nasdaq: PHVS), a clinical-stage company developing novel, oral bradykinin-B2-receptor
About this update from Pharvaris N.v.
[{"type":"text","content":"ZUG, Switzerland, May 06, 2023 (GLOBE NEWSWIRE) -- Pharvaris (Nasdaq: PHVS), a clinical-stage company developing novel, oral bradykinin-B2-receptor antagonists to treat and prevent hereditary angioedema (HAE) attacks, today announced two oral presentations and three poster presentations highlighting data from non-clinical and clinical studies of deucrictibant at the 13th C1-inhibitor Deficiency and Angioedema Workshop, being held from May 4-7, 2023, in Budapest, Hungary. “Today, two sequential presentations showed how PHVS416 (immediate-release deucrictibant capsules) provided symptom relief and resolution in the treatment of HAE attacks using the doses projected through the bradykinin challenge, our in vivo surrogate marker model,” said Peng Lu, M.D., Ph.D., Chief Medical Officer of Pharvaris. “The RAPIDe-1 study showed consistent and clinically meaningful results across all endpoints supporting the further development of PHVS416 as a potential on-demand therapy for HAE. We plan to leverage these findings to prepare for RAPIDe-3, our Phase 3 clinical study evaluating PHVS416 for the treatment of on-demand HAE attacks.” Anne Lesage, Ph.D., Chief Early Development Officer of Pharvaris, added, “The outcomes of the cardiovascular assessments in non-clinical studies, combined with the data from our clinical studies to date, support the cardiovascular tolerability and safety profile of deucrictibant for the potential treatment of HAE and other bradykinin-mediated diseases with unmet need.” Presentation details and key data highlights include: Title: The EC85 Derived from the Oral Bradykinin B2 Receptor Antagonist Deucrictibant (PHA121) Against Bradykinin Effects in Healthy Volunteers Predicts the Onset and Duration of Its Clinical Effects in Hereditary AngioedemaPresentation ID: O-18Presenter: Prof. Marcus Maurer, M.D. Date and Time: Saturday, May 6, 08:45-09:00 CEST (2:45-3:00 a.m. EDT)A bradykinin challenge model developed in non-human primates and healthy volunteers was employed to determine the plasma effective threshold for the bradykinin-antagonistic properties of deucrictibant in HAE and to predict the duration of the clinical effects of deucrictibant. Consistent with the modeling from the bradykinin challenge, a single dose of each of the PHVS416 (immediate-release deucrictibant capsules) doses in the RAPIDe-1 trial reached t...