Palvella Therapeutics Highlights Continued Progress Across Rare Skin Disease Pipeline with Two Poster Presentations at the 2026 American Academy of Dermatology Annual Meeting

Poster #76954 highlights QTORIN™ rapamycin’s single phase anhydrous gel formulation designed to optimize dermal bioavailability of rapamycin for mTOR-driven skin diseases while overcoming the crystallization, stability, and dermal penetration challenges posed by rapamycin

Poster #76929 highlights a qualitative patient and caregiver interview study evaluating the burden of living with porokeratosis, a serious, rare genetic skin disease characterized by numerous pre-cancerous, pruritic lesions and substantial functional and psychosocial burden

WAYNE, Pa., March 27, 2026 (GLOBE NEWSWIRE) -- Palvella Therapeutics, Inc., (“Palvella” or “the Company”) (Nasdaq: PVLA), a clinical-stage biopharmaceutical company focused on developing and commercializing novel therapies to treat patients suffering from serious, rare skin diseases and vascular malformations for which there are no U.S. Food and Drug Administration (FDA)-approved therapies, today announced two poster presentations at the 2026 American Academy of Dermatology Annual Meeting to be held March 27-31 in Denver, Colorado.

“The data presented in these posters highlight the innovative capabilities of the QTORIN™ platform as well as Palvella’s unwavering commitment to incorporating the voice of the patient in our development programs,” said Dr. Jeff Martini, Chief Scientific Officer of Palvella Therapeutics. “With patients in mind, we developed QTORIN™ rapamycin as a single-phase anhydrous gel designed to prevent crystallization and degradation of rapamycin with the goal of ensuring rapamycin bioavailability in the dermis, the site of disease pathology for many mTOR-driven skin diseases. Furthermore, our porokeratosis qualitative burden-of-living study, incorporating both patient and caregiver perspectives, confirms that porokeratosis is a life-altering condition with no FDA-approved therapies, imposing substantial physical, psychosocial, and cancer-related burdens that affect daily life in profound ways.”

The details of the poster presentations are as follows:

Poster #76954: QTORIN™ Rapamycin: Advancing Topical Formulation Science for Rare Dermatologic Diseases

QTORIN™ 3.9% rapamycin anhydrous gel (QTORIN™ rapamycin) was developed over many years by Palvella and an international team of leading topical formulation scientists. This work addressed rapamycin’s crystallization, stability, and skin penetration challenges, which have historically limited its use in skin diseases despite the identification of multiple mTOR pathway-driven conditions.

• QTORIN™ rapamycin is being developed under an active FDA-regulated Investigational New Drug application, with rigorous clinical, nonclinical, and chemistry, manufacturing, and controls evaluation, as well as manufacturing in accordance with current Good Manufacturing Practice (GMP) standards.
• Compounded rapamycin formulations do not undergo the FDA drug approval process and typically are not manufactured under GMP standards, which can contribute to poor solubility, instability, inconsistent drug delivery, and potential patient safety concerns.
• Microscopic evaluation of compounded rapamycin formulations revealed drug crystallization, indicating rapamycin was bound in crystals and therefore less available for skin penetration; notably, all compounded formulations tested demonstrated rapid chemical degradation when assayed for drug product stability.

Supporting QTORIN™ rapamycin’s potential in serious, rare skin diseases and vascular malformations, the Phase 3 SELVA study of QTORIN™ rapamycin in microcystic lymphatic malformations met its primary endpoint with statistically significant improvement on the Microcystic Lymphatic Malformation Investigator Global Assessment (mLM-IGA) (p