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Palisade Bio (Nasdaq: PALI) Announces Analysis Demonstrating LB1148 Reduced the Extent and Severity of Post-Surgical Intraabdominal Adhesions by 93%
Data from Pooled-Analysis of Enteral Protease Inhibitor LB1148 Demonstrated 72% Reduction in the Risk of Adhesion Formation in Patients Undergoing Bowel
About this update from Palisade Bio, Inc.
[{"type":"text","content":"Data from Pooled-Analysis of Enteral Protease Inhibitor LB1148 Demonstrated 72% Reduction in the Risk of Adhesion Formation in Patients Undergoing Bowel Resection Surgery Company to Host Conference Call on Wednesday, March 16, 2022, at 8:30 a.m. EDT CARLSBAD, Calif., March 16, 2022 (GLOBE NEWSWIRE) -- Palisade Bio, Inc. (Nasdaq: PALI), a clinical stage biopharmaceutical company advancing therapies for acute and chronic gastrointestinal (GI) complications, announced data from a Pooled-Analysis of Studies LBS-IST-POI-101 and LBS-POI-201-CN (PROFILE-CN.) These data are featured today at the Next Big Thing session of the Society of American Gastrointestinal and Endoscopic Surgeons (SAGES) 2022 Annual Meeting, being held in Denver, March 16-19. Highlights are: LB1148 reduced incidence of adhesions by 72% in patients undergoing bowel resectionLB1148 reduced extent and severity of adhesions by 93% in patients undergoing bowel resectionThe incidence of adhesions in the placebo group was similar to the published incidence (89% and ≥90% respectively)100% of placebo-treated subjects underwent a laparoscopic procedure, and 8 of 9 had ≥ 1 adhesions75% of the 8 LB1148-treated subjects underwent a laparoscopic procedure, and 2 of 6 had ≥ 1 adhesions 25% of the 8 LB1148-treated subjects underwent a laparotomy, and neither formed adhesions No drug-related serious adverse events occurred in the trials “The pooled results from these studies suggest that LB1148 has the potential to prevent postoperative adhesions,” said Michael Dawson, M.D., Chief Medical Officer of Palisade Bio. “There is significant unmet need to prevent and reduce adhesions, as they are found in more than 90% of cases after intraabdominal surgery and patients tend to suffer life-long complications. These data are promising as we focus on our mission of protecting intestinal integrity and improving treatment options for patients.” Studies LBS-IST-POI-101 and LBS-POI-201-CN (PROFILE-CN) assessed the efficacy of LB1148 to reduce the formation of adhesions in subjects undergoing abdominal surgery. Study LBS-IST-POI-101 was a Phase 1, single-center, open-label, study enrolling 11 subjects undergoing GI surgery. The PROFILE-CN study was a 120-subject Phase 2, randomized, double-blind, placebo-controlled study conducted in collaboration with co-development partner, Newsoara Biopharma t...