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Palisade Bio Announces European Patent Office Issued a Decision to Grant Notice for Patent for Lead Product Candidate, PALI-2108
Patent includes Composition of Matter claims for both PALI-2108 and PALI-1908 programs Patent includes broad claims for “Gut Microbiota Bioactivated PDE4
About this update from Palisade Bio, Inc.
[{"type":"text","content":"Patent includes Composition of Matter claims for both PALI-2108 and PALI-1908 programs Patent includes broad claims for “Gut Microbiota Bioactivated PDE4 Inhibitor Precursors” with similar structure to PALI-2108 and PALI-1908 This patent family provides Composition of Matter coverage beyond 2042 PALI-2108 is in development to treat patients with active moderate-to-severely active Ulcerative Colitis (UC) PALI-1908 is in development to treat patients with active fibro stenotic Crohn’s Disease (CD) Carlsbad, CA, July 19, 2024 (GLOBE NEWSWIRE) -- Palisade Bio, Inc. (Nasdaq: PALI) (the “Company”), a biopharmaceutical company focused on developing and advancing novel therapeutics for patients living with autoimmune, inflammatory, and fibrotic diseases, today announced that European Patent Office (EPO) has issued a decision to grant notice for patent number 4,157,853 titled, “Gut Microbiota Bioactivated PDE4 Inhibitor Precursors.” Based on the intention to grant notice, the Company expects the EPO to issue a patent July 31, 2024. In addition to this European patent and recently allowed Canadian patent, the Company continues to strengthen its global intellectual property portfolio surrounding PALI-2108 with submitted and planned submissions of additional patent applications. J.D. Finley, Chief Executive Officer of Palisade commented, “We are pleased to further expand our global patent estate for our PALI-2108 and PALI-1908 programs with this European patent. PALI-2108 continues to demonstrate encouraging data and bolster our confidence in its potential as a next-generation therapeutic option for patients with inflammatory bowel disease. As we continue to execute on the development pathway forward for PALI-2108 and PALI-1908, we remain committed to strengthening our global intellectual property portfolio.” The patent claims include coverage for the proprietary composition of PALI-2108, the Company’s orally administered, locally acting colon-specific Phosphodiesterase-4 (PDE4) inhibitor prodrug in development for patients affected by Ulcerative Colitis (UC). PALI-2108’s unique design, incorporating a galactose-derived sugar moiety, potentially allows for minimal absorption until cleaved by the colonic bacterium enzyme β-glucuronidase. This feature is intended to ensure localized bioactivation, leading to colon-specific distribution with l...