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PacBio Announces Major Advances for Revio and Vega to Lower Genome Cost and Expand Multiomic Capabilities
New SPRQ-Nx chemistry designed to deliver the most complete view of the genome for less than $300 at scale MENLO PARK, Calif., Oct. 14, 2025 (GLOBE NEWSWIRE)
About this update from Pacific Biosciences Of California, Inc.
[{"type":"text","content":"New SPRQ-Nx chemistry designed to deliver the most complete view of the genome for less than $300 at scale\nMENLO PARK, Calif., Oct. 14, 2025 (GLOBE NEWSWIRE) -- PacBio (NASDAQ: PACB), developer of the world's most advanced sequencing technologies, today announced innovations to its Revio and Vega platforms designed to lower sequencing costs, add new multiomic capabilities, and expand support for regulated research environments. The advancements center on new SPRQ-Nx sequencing chemistry and consumables, which are designed to deliver PacBio’s most affordable HiFi genome to date. Customers operating at scale could see as much as a 40% reduction from current costs, down to a price of less than $300 per genome. Additional improvements include 5hmC detection for epigenetic profiling and 21 CFR Part 11 compliance features for Vega. These updates reflect PacBio’s continued investment in making its highly accurate long-read sequencing solutions accessible at scale for population genomics, clinical research, and production-scale environments. Beta testing of SPRQ-Nx chemistry on the higher throughput Revio is expected to begin in November 2025, with full commercial availability planned in 2026. Beta participants will be able to purchase 384 genomes of sequencing reagents for approximately $250 per genome. At launch, Revio systems running SPRQ-Nx will produce complete, multiomic native long-read genomes at the lowest cost in the market. PacBio intends to achieve these cost savings by enabling multiple runs per SMRT Cell while maintaining output per run, which will improve efficiency, reduce waste, and preserve PacBio’s hallmark accuracy and data richness. “With lower sequencing costs, deeper biological insights, and new capabilities for clinical research and production-scale labs, we are delivering on our goal to make HiFi sequencing accessible for every genome and every lab,” said Christian Henry, President and Chief Executive Officer of PacBio. “From early discussions with customers, we’re seeing funding for projects at a larger scale than we’ve seen in the past. Our new pricing will allow researchers to apply the richness of HiFi data to many applications requiring more genomes, especially those leveraging large sample numbers to build robust AI models.” Vega, PacBio’s benchtop system, will integrate SPRQ-Nx chemistry and 5hmC detecti...