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Omeros Announces Publication of Study Showing that Inhibition of MASP-2, the Key Enzyme of the Complement System’s Lectin Pathway, Protects Against Renal Injury Caused by Proteinuria
SEATTLE--(BUSINESS WIRE)-- Omeros Corporation (Nasdaq: OMER) today announced publication of study results showing that inhibition of mannan-binding
About this update from Omeros Corporation
[{"type":"text","content":" SEATTLE--(BUSINESS WIRE)--\nOmeros Corporation (Nasdaq: OMER) today announced publication of study results showing that inhibition of mannan-binding lectin-associated serine protease-2 (MASP-2) protects against renal injury caused by proteinuria (i.e., high levels of plasma proteins in the urine) and inflammation. The article, published in Frontiers in Immunology and entitled “Absence of the Lectin Activation Pathway of Complement Ameliorates Proteinuria-Induced Renal Injury,” can be accessed online at https://www.frontiersin.org/articles/10.3389/fimmu.2019.02238/full.\n\n\nThe study used a well-established animal model of proteinuria to determine the effect of MASP-2 inhibition on renal injury and fibrotic changes characteristic of proteinuric kidney diseases, including immunoglobulin A (IgA) nephropathy and lupus nephritis, which can often lead to end-stage kidney disease and dialysis. Both MASP-2-deficient and MASP-2 inhibitor-treated animals demonstrated marked renoprotection and reduction in inflammation from proteinuria with significantly less tubulointerstitial injury when compared to isotype antibody‑treated controls. Collectively, these findings indicate that MASP-2 inhibition may be broadly protective in proteinuric nephropathies.\n\n\nOmeros’ lead MASP-2 inhibitor narsoplimab is in Phase 3 clinical programs for the treatment of IgA nephropathy and of atypical hemolytic uremic syndrome. In addition, Omeros plans to begin submitting to FDA in the first half of next quarter a biologics license application for narsoplimab for the treatment of hematopoietic stem cell transplant-associated thrombotic microangiopathy. The company is also preparing a marketing authorization application requesting approval for this same indication in Europe.\n\n\nAbout Omeros Corporation\n\n\nOmeros is a commercial-stage biopharmaceutical company committed to discovering, developing and commercializing small-molecule and protein therapeutics for large-market as well as orphan indications targeting inflammation, complement-mediated diseases, disorders of the central nervous system and immune-related diseases, including cancers. The company’s drug product OMIDRIA (phenylephrine and ketorolac intraocular solution) 1% / 0.3% is marketed in the U.S. for use during cataract surgery or intraocular lens (IOL) replacement to maintain pupil size by pre...