Business
Nuwellis Announces Peer-Reviewed Publication of Clinical Trials Analysis Advocating the Use of Ultrafiltration for Heart Failure Patients Resistant to Diuretics
MINNEAPOLIS, March 21, 2023 (GLOBE NEWSWIRE) -- Nuwellis, Inc. (Nasdaq: NUWE), a medical technology company focused on transforming the lives of people with
About this update from Nuwellis, Inc.
[{"type":"text","content":"MINNEAPOLIS, March 21, 2023 (GLOBE NEWSWIRE) -- Nuwellis, Inc. (Nasdaq: NUWE), a medical technology company focused on transforming the lives of people with fluid overload, today announced the peer-reviewed publication of an analysis of available ultrafiltration clinical trials with findings that support ultrafiltration as a safe and effective therapeutic option for acute decompensated heart failure (ADHF) patients who are resistant to diuretics or who have a history of multiple hospitalizations for fluid overload. The publication highlights the scale of clinical burden: “ADHF has the highest rate of hospital readmissions among all medical conditions and portends a significant financial burden on healthcare systems worldwide.”1 The publication, “Extracorporeal Ultrafiltration for Acute Heart Failure,” featured in Cardiorenal Medicine Journal, includes the review of pooled data from seven randomized controlled trials of ultrafiltration with a total of 771 patient participants. A. Kazory, et al, highlight the clinical application and value of ultrafiltration, including: Predictable, adjustable, and more efficient fluid removal with ultrafiltration compared to diuretics, without clinically adverse impact on renal function, leads to a reduction in hospital readmissions and financial burden;Applicability of ultrafiltration therapy in other clinical settings, such as cardiac surgery, burn and other specialty units, where active and prompt volume management is of utmost importance; andExpansion of use of ultrafiltration into outpatient centers and other ambulatory settings. John Jefferies, M.D., Chief Medical Officer of Nuwellis, said, “Hospitalizations for ADHF are primarily driven by fluid overload, with nearly 50% of these patients leaving the hospital with inadequate or minimal weight loss, in part due to unpredictability of diuretic therapy. As such, it also has the highest rehospitalization rate among all medical conditions.” Dr. Jefferies added, “Ultrafiltration, however, provides an opportunity to overcome the shortcomings of diuretics, as the Aquadex® system’s decongestion technique safely provides for adjustable fluid and sodium removal. It can also be considered early after admission, with volume and rate of fluid removal specific to patient characteristics for more predictable results, which diuretics often times cannot ach...