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Nuwellis Announces New Clinical Data Demonstrating 100% Survival at 30 Days Following Use of Ultrafiltration in High-Risk Postoperative Coronary Artery Bypass Grafting (CABG) Patients
Data show ultrafiltration for post-operative CABG patients provides a safe and effective method for managing fluid balance and reducing mortality rates
About this update from Nuwellis, Inc.
[{"type":"text","content":"Data show ultrafiltration for post-operative CABG patients provides a safe and effective method for managing fluid balance and reducing mortality rates\nMINNEAPOLIS, Aug. 31, 2022 (GLOBE NEWSWIRE) -- Nuwellis, Inc. (Nasdaq: NUWE), a commercial-stage company focused on transforming the lives of people with fluid overload, today announced the publication of key clinical data supporting the use of ultrafiltration with the Aquadex FlexFlow® System in high-risk postoperative coronary artery bypass grafting (CABG) patients in the Journal of Cardiac Surgery. The study, “The Use of Simple Ultrafiltration Technology as a Fluid Management Strategy for High-Risk Coronary Artery Bypass Grafting Surgery,” is a real-world retrospective review of postoperative isolated CABG patients who were treated in the Division of Cardiothoracic Surgery at Baylor Scott & White Health in Temple, Texas between January 1, 2020 and July 31, 2021. A total of 254 CABG procedures were performed during this period, and ultrafiltration was used in 17 (6.7%) patients. Despite an elevated mean Society of Thoracic Surgeons mortality score of 5.7% (range 0.6-50.0), the 30-day survival rate of patients treated with ultrafiltration was 100%. “Ultrafiltration technology has been used for decades to successfully treat advanced heart failure patients and data hav been published to demonstrate its outcomes, but its application in cardiac surgery to treat fluid overload is innovative,” said Daniel Beckles, M.D., Surgical Director of Heart Transplantation and Mechanical Circulatory Support at Baylor Scott & White Health and the study’s lead author. “These favorable results are consistent with the clinical findings in other large academic centers using ultrafiltration technology in cardiac surgery, and we are eager to gather additional multi-institutional data about the use of Aquadex for this challenging patient population.” According to the Society of Thoracic Surgery Adult Cardiac Surgery Database, isolated CABG for coronary artery disease (CAD) is the most commonly performed cardiac surgery procedure, with over 162,000 per year.1 The increased age of patients, in addition to risk factors for CAD (hypertension, diabetes, obesity and chronic kidney disease), increases the perioperative risk for acute kidney injury and subsequent fluid overload. Excess fluid overload in the pe...