Business
Nurix Therapeutics Presents Preclinical Data at 62nd American Society of Hematology (ASH) Annual Meeting and Exposition
Data support a planned clinical trial of NX-2127 in B-cell malignancies SAN FRANCISCO, Dec. 07, 2020 (GLOBE NEWSWIRE) -- Nurix Therapeutics, Inc. (Nasdaq:
About this update from Nurix Therapeutics, Inc.
[{"type":"text","content":"Data support a planned clinical trial of NX-2127 in B-cell malignancies\nSAN FRANCISCO, Dec. 07, 2020 (GLOBE NEWSWIRE) -- Nurix Therapeutics, Inc. (Nasdaq: NRIX), a biopharmaceutical company developing targeted protein modulation drugs, today announced the presentation of key preclinical data from its lead program, NX-2127, for the potential treatment of B-cell malignancies, at the 62nd American Society of Hematology (ASH) Annual Meeting and Exposition. Supported by these data, Nurix plans to initiate a Phase 1 clinical trial of orally administered NX-2127 in patients with relapsed or refractory non-Hodgkin’s lymphoma (NHL) and chronic lymphocytic leukemia (CLL) in the first half of 2021. “The data presented at ASH demonstrate the unique dual properties of NX-2127 which is designed to overcome treatment failures including resistance to approved agents while simultaneously activating additional cancer-fighting immune cells,” said Robert Brown, M.D., vice president of clinical development of Nurix. “We look forward to advancing our novel targeted protein dual degrader to the clinic for patients with B-cell malignancies who have failed to respond to currently available therapies.” NX-2127 catalyzes proteasomal degradation of Bruton’s tyrosine kinase (BTK), an enzyme involved in B-cell development, differentiation and signaling that is critical for proliferation and survival of lymphoma and leukemia cells in many B-cell malignancies, including NHL and CLL. Inhibitors of BTK, such as ibrutinib, are approved for treatment of B-cell cancers, however specific mutations can arise in the BTK protein that confer resistance to these agents, thereby reducing their efficacy. Degradation of BTK has the potential to overcome resistance in patients harboring such mutations in BTK. In addition, NX-2127 catalyzes degradation of a transcription factor involved in regulating T-cell function, resulting in T-cell activation in a similar fashion to immunomodulatory imide drugs (IMiD) that have demonstrated efficacy in some aggressive B-cell malignancies. The data presented at ASH demonstrate that NX-2127 catalyzes potent and selective degradation of both wild type and ibrutinib-resistant mutant BTK (BTKC481S) in lymphoma cell lines and inhibits their growth. In addition, NX-2127 treatment of normal human T-cells results in their activation with similar...