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Nurix Therapeutics Presents Data from Studies of Its Targeted Protein Degraders in B Cell Malignancies and Initiates Expansion of NX-2127 Phase 1b Trial in Diffuse Large B Cell Lymphoma and Mantle Cell Lymphoma Indications
Initiation of NX-2127 Phase 1b expansion cohort in patients with diffuse large B cell lymphoma (DLBCL) was informed by a rapid and sustained complete
About this update from Nurix Therapeutics, Inc.
[{"type":"text","content":"Initiation of NX-2127 Phase 1b expansion cohort in patients with diffuse large B cell lymphoma (DLBCL) was informed by a rapid and sustained complete response; Phase 1b expansion cohort also initiated in patients with mantle cell lymphoma (MCL) Clinical biomarker data from Phase 1a trial of NX-5948 demonstrate rapid, robust, and sustained degradation of Bruton’s tyrosine kinase (BTK) and support ongoing investigation of B cell malignancies NX-5948 crosses the blood brain barrier and catalyzes robust and efficient degradation of BTK, improving survival in an intracranial patient-cell-derived preclinical model of central nervous system (CNS) lymphoma SAN FRANCISCO, June 14, 2023 (GLOBE NEWSWIRE) -- Nurix Therapeutics, Inc. (Nasdaq: NRIX), a clinical-stage biopharmaceutical company developing targeted protein modulation drugs designed to treat patients with hematologic malignancies and solid tumors, today announced the presentation of clinical and preclinical data from its targeted protein degradation programs, NX-5948 and NX-2127, which are being evaluated in ongoing Phase 1 clinical trials in patients with relapsed/refractory B cell malignancies. These data are being presented at the 17th International Conference on Malignant Lymphoma (ICML) which is being held June 13-17, in Lugano, Switzerland. “The positive data emerging from our two targeted BTK degrader clinical programs are guiding our strategy on how best to deploy each drug candidate’s strengths and have informed our decision to initiate Phase 1b dose expansion for NX-2127 in patients with DLBCL and MCL where this drug has been well tolerated and has shown promising activity,” said Robert J. Brown, M.D., executive vice president and head of early clinical development at Nurix. “The observed rapid and sustained complete response with NX-2127 as a once daily oral single agent therapy in a relapsed/refractory patient with DLBCL supports our decision to advance this program into a Phase 1b expansion cohort. This exciting result is consistent with our findings in other non-Hodgkin lymphoma indications such as mantle cell lymphoma.” Both orally available compounds are efficient degraders of BTK, a key therapeutic target in the treatment of B-cell malignancies including primary CNS lymphoma. Limitations of current covalent and non-covalent BTK inhibitors include the susceptibili...