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Nurix Therapeutics Presents Beneficial Effects of CBL-B Inhibition on Human Tumor Infiltrating Lymphocytes at SITC Conference
DeTIL-0255 is a drug-enhanced investigational new cell therapy product candidate with potentially superior T cell properties compared to conventional TIL
About this update from Nurix Therapeutics, Inc.
[{"type":"text","content":"DeTIL-0255 is a drug-enhanced investigational new cell therapy product candidate with potentially superior T cell properties compared to conventional TIL Michael T. Lotze, Nurix’s chief cellular therapy officer, is awarded Lifetime Achievement award by SITC at its annual meeting SAN FRANCISCO, Nov. 12, 2021 (GLOBE NEWSWIRE) -- Nurix Therapeutics, Inc. (Nasdaq: NRIX), a biopharmaceutical company developing targeted protein modulation drugs, today announced the presentation of preclinical studies demonstrating that its CBL-B inhibitor, NX-0255, enhances the number and quality of T cells expanded from tumors for use in tumor infiltrating lymphocyte (TIL) therapy. These results will be presented by Nurix in a poster session at the Society for Immunotherapy of Cancer (SITC) conference held at the Washington Convention Center on Saturday, November 13. Nurix also congratulates Michael T. Lotze, M.D., Nurix’s chief cellular therapy officer (CCO), who will be honored at the conference with the 2021 SITC Lifetime Achievement Award. “Throughout the history of tumor infiltrating lymphocyte therapy, certain patients with melanoma and several other solid tumor types have experienced extraordinarily durable tumor responses,” said Dr. Lotze. “With our small molecule CBL-B inhibitors, we hope to broaden and deepen such responses across a range of solid tumors using our drug-enhanced TIL therapy, DeTIL-0255.” As a key step toward advancing DeTIL-0255 into the clinic, Nurix performed a series of experiments on human tumors to characterize the effects of CBL-B inhibition using NX-0255 on the production and quality of TIL. Tumor samples were obtained from 16 patients with ovary, colon, lung, head and neck, breast, or vulva carcinomas. Tumors from patients were cultured either in the presence of recombinant human IL-2 (rhIL-2) alone to generate TIL or in combination with NX-0255 + rhIL-2 to generate DeTIL-0255, Nurix’s cell therapy clinical candidate. Compared to TIL, DeTIL-0255 demonstrated: Increased T cell expansion (p","length":2693,"tagName":"div"}]