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NurExone Biologic Announces Preclinical Evidence of Structural Repair in Injured Spinal Cord Tissue following ExoPTEN Treatment
TORONTO and HAIFA, Israel, Aug. 20, 2025 (GLOBE NEWSWIRE) -- NurExone Biologic Inc. (TSXV: NRX) (...
About this update from Nurexone Biologic Inc
[{"type":"text","content":"NurExone Biologic Announces Preclinical Evidence of Structural Repair in Injured Spinal Cord Tissue following ExoPTEN TreatmentC$0.78 Million Private Placement Successfully Closed\n\n\n\n TORONTO and HAIFA, Israel, Aug. 20, 2025 (GLOBE NEWSWIRE) -- NurExone Biologic Inc. (TSXV: NRX) (OTCQB: NRXBF) (FSE: J90) (“\n \n NurExone\n \n ” or the “\n \n Company\n \n ”) is pleased to announce new preclinical imaging results providing anatomical evidence consistent with structural repair of spinal cord following treatment with ExoPTEN.\n \n\n An imaging-based analysis of animals treated with ExoPTEN after a spinal cord injury showed more organized spinal cord tissue compared to untreated controls. A functional assessment of this same cohort showing that 100% of animals in a higher-dose group regained motor function was\n \n\n published in July 2025\n \n\n .\n \n\n “The data from the MRI with Diffusion Tensor Imaging (“\n \n MRI-DTI\n \n ”) indicates that the injured spinal cords showed greater structural integrity and tissue organization when treated with ExoPTEN in the animal model. Importantly, those structurally preserved spinal cords strengthen the accumulating evidence of ExoPTEN neuroprotective and regeneration-promoting activity following spinal cord injury,” said Dr. Kineret Taler, Head of Preclinical Studies.\n \n\n\n Unmet Need in Spinal Cord Injury and Evidence of Spinal Cord Repair\n \n\n\n Spinal cord injury is life-altering and imposes a substantial healthcare and economic burden. Current treatments focus on stabilizing patients but do not repair damaged tissue. ExoPTEN is designed to support nerve repair and restore function. NurExone continues preparations for its first-in-human clinical trial of ExoPTEN, subject to regulatory approval.\n \n\n MRI-DTI is an advanced imaging technique that maps the movement of water molecules in tissue, providing a detailed view of microstructural integrity beyond conventional MRI and effectively shows a spinal cord’s wiring.\n \n\n\n Two key parameters are used:\n \n\n\n\n Fractional Anisotropy (“\n \n FA\n \n ”): Indicates alignment and preservation of nerve fibers. Higher FA values indicate stronger structural integrity.\n \n\n Mean Diffusivity (“\n \n MD\n \n ”): Reflects microscopic tissue archit...