Business
Novocure Announces Review Article of Anti-Cancer Mechanisms of Action of Tumor Treating Fields Published in Journal of Molecular Cell Biology
A fast-growing body of research, both in vitro and in vivo, is converging to demonstrate the multiple inhibitory effects of Tumor Treating Fields on cancer
About this update from Novocure Limited
[{"type":"text","content":"\nA fast-growing body of research, both in vitro and in vivo, is converging to demonstrate the multiple inhibitory effects of Tumor Treating Fields on cancer growth\n\nThe review article summarizes the known mechanisms of action of Tumor Treating Fields that have been reported by in vitro and in vivo studies of cancer\n\n ROOT, Switzerland--(BUSINESS WIRE)--\nNovocure (NASDAQ: NVCR) today announced a review article of anti-cancer mechanisms of action of Tumor Treating Fields (TTFields) has been published in the Journal of Molecular Cell Biology (JMCB).\n\nThe review article, written by Shadi Shams of Rowan University School of Osteopathic Medicine and Chirag B. Patel, MD, PhD, Assistant Professor and McNair Scholar, Department of Neuro-Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center in Houston, summarizes the known mechanisms of action of TTFields that have been reported by in vitro and in vivo studies of cancer. TTFields are electric fields that exert physical forces to kill cancer cells via a variety of mechanisms. TTFields do not significantly affect healthy cells because they have different properties (including division rate, morphology and electrical properties) than cancer cells.\n\nThe review article cites that many studies to date have focused on TTFields’ effect on cancer cell division. More recently, research has demonstrated the effects of TTFields expand beyond preventing cancer cell division. The multiple, distinct mechanisms of TTFields therapy work together to selectively target and kill cancer cells. Along with disruption of mitosis, the review article states that preclinical research has also shown interference with cancer cell motility and migration, activation of downstream anti-tumor immunity, downregulation of genes important for DNA damage repair, and other potential mechanisms. Due to its multimechanistic actions, TTFields therapy can be added to cancer treatment modalities in approved indications and demonstrates enhanced effects across solid tumor types when used with chemotherapy, radiotherapy, immune checkpoint inhibition, or PARP inhibition in preclinical models.\n\n“A fast-growing body of research, both in vitro and in vivo, is converging to demonstrate the multiple inhibitory effects of TTFields on cancer growth,” the article states.\n\nShams and Patel state...