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Novocure Announces Recipients of 4th Annual AACR-Novocure Grants for Tumor Treating Fields Research Program
Awards aim to promote and support innovative research on Tumor Treating Fields to deepen understanding and accelerate the development of new treatment
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[{"type":"text","content":"\nAwards aim to promote and support innovative research on Tumor Treating Fields to deepen understanding and accelerate the development of new treatment strategies\n\n ROOT, Switzerland--(BUSINESS WIRE)--\nNovocure today announced the recipients of the 4th Annual AACR-Novocure Grants for Tumor Treating Fields Research Program. The AACR-Novocure Grants for Tumor Treating Fields Research Program represents a joint effort between Novocure and the American Association for Cancer Research (AACR) to promote and support innovative research on Tumor Treating Fields (TTFields). The AACR is the world’s first and largest professional organization dedicated to advancing cancer research and its mission to prevent and cure cancer.\n\nSuch collaborations help to deepen the understanding of TTFields’ mechanism of action and to identify its optimal use. Extensive preclinical and clinical evidence provides the foundation upon which Novocure executes its strategy to advance TTFields through additional clinical research studies across multiple solid tumor types.\n\nProfessor Wafik El-Deiry, M.D., Ph.D., FACP, Director of the Legorreta Cancer Center at Brown University and Associate Dean for Oncologic Sciences at the Warren Alpert Medical School, is one of the grant recipients. His hypothesis is based on a prediction that therapeutic agents that trigger cell stress pathways in different ways may cooperate to achieve a greater therapeutic effect in various cancers.\n\nOver the past year, Dr. El-Deiry, an expert in cancer biology, has become interested in TTFields and their potential to affect the integrated stress response, a signaling network within cells that is related to their survival. His research group will combine TTFields with other therapies, including the oral drug ONC201, and study how the combinations affect the integrated stress response in various cancer types.\n\n“I’m a practicing clinical oncologist. I see patients every week,” said Dr. El-Deiry. “I’m well aware of the genes that contribute to tumor progression, drug resistance, and failure of the immune response, and clearly we need to do better. There’s a certain skillset that I think we have, to be able to design and propose rational combinations in different tumor types to achieve tumor regression with limited toxicity. I look forward to researching how TTFields, when used in com...