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Preclinical Study Builds on Growing Body of Evidence Showcasing Exogenous Nicotinamide Mononucleotide (NMN) Must be Converted to Nicotinamide Riboside (NR), Making NR a More Efficient Nicotinamide Adenine Dinucleotide (NAD+) Precursor to NMN
This study, which utilized the gold standard method of stable isotopes, reinforces that NMN cannot cross the cell membrane directly and must first be
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[{"type":"text","content":"\nThis study, which utilized the gold standard method of stable isotopes, reinforces that NMN cannot cross the cell membrane directly and must first be converted to NR\n\n\n LOS ANGELES--(BUSINESS WIRE)--\nChromaDex Corp. (NASDAQ:CDXC), a global authority on Nicotinamide Adenine Dinucleotide (NAD+) research and healthy aging, shares findings from a preclinical study, as reported in the peer-reviewed journal International Journal of Molecular Sciences by a team of scientists led by Dr. Yue Yang, Assistant Professor of Research in Pharmacology at Weill Cornell Medicine in New York.\n\nThis press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20230824959294/en/Outside of the cell, NMN cannot cross the cell barrier directly and must first be converted to NR (Graphic: Business Wire)\nThis preclinical study utilized stable isotopes, the gold standard method in research, to assess the metabolic fate of nicotinamide mononucleotide (NMN). The results indicate that NMN is primarily converted to nicotinamide and nicotinamide riboside (NR) before being utilized for NAD+ synthesis, with only a small portion of NMN being directly incorporated into NAD+. These results build on a growing body of research demonstrating that NMN cannot cross the cell membrane directly and must first be converted to NR. Because NR can cross the cell membrane directly, this data, along with other science, indicates that NR is a more efficient NAD+ precursor than NMN.\n\n\n“The research overwhelmingly demonstrates that NMN obtained from the diet or supplementation is a precursor to NR as NMN cannot efficiently cross the cell membrane and suggests NR is more efficient at increasing NAD+ levels,” said Dr. Anthony Covarrubias, Principal Investigator at UCLA David Geffen School of Medicine, Department of Microbiology, Immunology, and Molecular Genetics, UCLA Metabolism and Immunology Theme Space, who was not involved in the study.\n\n\nAlthough NAD+ was discovered over a century ago, interest in the science around NAD+ biology has ignited due to the recent discovery of NR and NMN’s ability to boost bioavailable NAD+. However, in November 2022, the U.S. Food & Drug Administration determined that NMN could no longer be sold as a dietary supplement. This decision has no impact on NR, which is a chemically and biologically di...