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Milestone Phase II Clinical Study Demonstrates Niagen®, Patented Nicotinamide Riboside (NR), Improves Functional Mobility for Individuals with Peripheral Artery Disease (PAD)
NR improved the six-minute walking distance and treadmill walking time for those with PAD LOS ANGELES--(BUSINESS WIRE)-- ChromaDex Corp. (NASDAQ:CDXC), the
About this update from Niagen Bioscience, Inc.
[{"type":"text","content":"\nNR improved the six-minute walking distance and treadmill walking time for those with PAD\n\n\n LOS ANGELES--(BUSINESS WIRE)--\nChromaDex Corp. (NASDAQ:CDXC), the global authority on nicotinamide adenine dinucleotide (NAD+) research, shares results from a milestone phase II clinical study showcasing the promising effects of nicotinamide riboside (NR) supplementation for people with peripheral artery disease (PAD). This study was part of the ChromaDex External Research Program (CERP®), which donated ChromaDex’s patented NR ingredient, Niagen®, the most efficient and high-quality NAD+ precursor, for the advancement of this research.\n\n\nAs reported in the peer-reviewed journal Nature Communications by a team of scientists led by Dr. Mary M. McDermott, Northwestern University Feinberg School of Medicine, Chicago, results underscored the functional mobility benefits of NR such as an improvement in treadmill walking time and a statistically significant and clinically meaningful improvement in the six-minute walking distance in individuals with PAD.\n\n\nDr. McDermott commented, “In this Phase II clinical trial, NR improved 6-minute walk distance and treadmill walking time in people with PAD, compared to placebo. These promising results require confirmation in a larger definitive randomized clinical trial.”\n\n\nAbout PAD and the NAD+ connection\n\n\nA prevalent condition impacting over 200 million people worldwide, PAD is characterized by a narrowing or blockage of arteries that reduces blood flow to the limbs, causing severe pain and walking disabilities due to insufficient blood flow and reduced oxygen supply. Existing treatments for PAD are often limited in their effectiveness, underscoring the need for novel therapeutic approaches.\n\n\nAs the most efficient NAD+ precursor, NR has been proven safe and effective in elevating NAD+ levels in humans (Conze et al., 2019, Martens et al., 2018, Trammell et al., 2016). Preclinical and clinical studies have shown that boosting NAD+ levels with NR can enhance skeletal muscle health, mitochondrial performance, and vascular health (Lapatto et al., 2023, Elhassan et al., 2019, Zhang et al., 2016). As NAD+ levels decline with age and given the high incidence of PAD among older individuals, increasing NAD+ with NR may reduce oxidative stress and improve mitochondrial and endothelial cell fun...