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ChromaDex Announces Results of New Pilot Clinical Trial Showing Anti-Inflammatory Effects of Nicotinamide Riboside (NR) Supplementation
Researchers publish new clinical data on NR supplementation, marking the 18th clinical trial on ChromaDex’s Niagen® ingredient LOS ANGELES--(BUSINESS WIRE)--
About this update from Niagen Bioscience, Inc.
[{"type":"text","content":"\nResearchers publish new clinical data on NR supplementation, marking the 18th clinical trial on ChromaDex’s Niagen® ingredient\n\n LOS ANGELES--(BUSINESS WIRE)--\nChromaDex Corp. (NASDAQ:CDXC) today announced results of the 18th clinical trial on its flagship Niagen® (patented nicotinamide riboside, or “NR”) ingredient with promising, peer-reviewed findings reported in the Journal of Clinical Investigation. The study investigated the anti-inflammatory effects of ChromaDex’s proprietary NR ingredient in monocytes (a type of white blood cell) extracted from two groups: young, healthy subjects and patients diagnosed with systemic lupus erythematosus (SLE). The study was conducted as part of the ChromaDex External Research Program (CERP™) and adds to a growing body of clinical evidence supporting the potential anti-inflammatory effects of NR supplementation.\n\nResults showed that increasing NAD+ levels through NR supplementation reduced Type-I interferon (IFN) signaling (which plays an important role in the human immune response) in human monocytes both in vivo in a young, healthy population and ex vivo in monocytes extracted from control subjects and SLE patients.\n\n“This study supplies a mechanistic foundation as to how NR blunts monocyte immunity and supports the need for future studies in patients with monocyte-driven inflammatory disease,” said study lead Michael N. Sack, M.D., Ph.D., a senior investigator in the Laboratory of Mitochondrial Biology and Metabolism at the National Heart, Lung, and Blood Institute at the National Institutes of Health (NIH).\n\nThis randomized, double-blinded, placebo-controlled pilot study featured 35 healthy volunteers (average age of 24 and average BMI of 24 kg/m2) that were supplemented with 1000mg NR or placebo for 7 days. Extracted white blood cells from these young, healthy subjects as well as from middle-aged lupus patients and matched controls were then exposed to an inflammation inducer to assess NR’s anti-inflammatory effects.\n\n“The results from this pilot study showing an immunomodulatory effect of NR through decreased IFN levels are promising; however, more research is needed to understand the implications of NR supplementation for patients with autoimmune disorders like lupus,” said Dr. Andrew Shao, Senior Vice President of Global Regulatory & Scientific Affairs at ChromaDex. “W...