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Neurotrope Announces Publication Highlighting the Potential of Bryostatin as a Unique Neurorestorative Therapy
NEW YORK, Aug. 13, 2019 /PRNewswire/ -- Neurotrope, Inc. (Nasdaq: NTRP), a clinical-stage biopharmaceutical company developing novel therapies for
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[{"type":"text","content":" NEW YORK, Aug. 13, 2019 /PRNewswire/ -- Neurotrope, Inc. (Nasdaq: NTRP), a clinical-stage biopharmaceutical company developing novel therapies for neurodegenerative diseases, including Alzheimer's disease (AD), today announced that an article highlighting the synaptic deficiency hypothesis was published online in Trends in Pharmacological Sciences. This article presents an overview of the previous nonpharmacological interventions and pharmacological agents, including Bryostatin, that target synaptic functions in order to improve cognitive functions against AD-related memory impairment. The publication emphasizes that restoring synaptic functions should be considered as one of the major therapeutic goals in the treatment of AD patients. \n\"Alzheimer's disease, the leading disorder of memory impairment in our aging population, is increasing at an alarming rate and clinical trials targeting neurotoxic amyloid beta have consistently failed to produce therapeutic effects on memory function in AD patients,\" said Dr. Daniel Alkon, Neurotrope's Chief Scientific Officer. \"Leveraging decades of work on the protein kinase C (PKC) - BDNF pathway in memory storage at NIH and other leading institutions, bryostatin (not a statin for lowering cholesterol) uses a novel mechanism of action to generate new, mature synaptic connections and prevent neuronal death in AD models.\"\n\"Our confirmatory Phase 2 trial is based on clinical data from our previous exploratory Phase 2 trial, which showed significant improvements in Severe Impairment Battery (SIB) scores for patients in the 20µg Bryostatin-1 dose group not on memantine,\" Dr. Alkon continued. \"We look forward to reporting top-line data from this confirmatory Phase 2 study during the third quarter of 2019, which could be a critical point of validation for the regenerative potential of bryostatin as a treatment for patients with moderate to severe AD.\"\nThe article, entitled Neuro-regeneration Therapeutic for Alzheimer's Dementia: Perspectives on Neurotrophic Activity, explores the synaptic deficiency hypothesis and therapeutic strategies that have potential to restore synaptic numbers reduced by neurodegeneration. Brain-derived neurotrophic factor (BDNF) plays essential roles in cell proliferation, neurogenesis, cognition, and synaptic integrity. The BDNF signaling pathways in the brain a...