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Dr. Brahm Segal appointed to NextCure Scientific Advisory Board; NextCure and Roswell Park Shared Nonclinical Data on the Impact of NC410 Blockade on Neutrophil-mediated T Cell Suppression at the 24th Translational Research Cancer Centers Consortium A...
Dr. Brahm Segal appointed to NextCure Scientific Advisory Board; NextCure and Roswell Park Shared Nonclinical Data on the Impact of NC410 Blockade on
About this update from Nextcure, Inc.
[{"type":"text","content":"Dr. Brahm Segal appointed to NextCure Scientific Advisory Board; NextCure and Roswell Park Shared Nonclinical Data on the Impact of NC410 Blockade on Neutrophil-mediated T Cell Suppression at the 24th Translational Research Cancer Centers Consortium Annual Meeting \n BELTSVILLE, Md., June 22, 2022 (GLOBE NEWSWIRE) -- NextCure, Inc. (Nasdaq: NXTC), a clinical-stage biopharmaceutical company committed to discovering and developing novel, first-in-class immunomedicines to treat cancer and other immune-related diseases, today announced that collaborator Brahm Segal, M.D., of Roswell Park Comprehensive Cancer Center shared nonclinical data from a research study that models the ability of NC410 to block neutrophil-mediated suppression of T cells in a tumor microenvironment (TME) at the 24th Translational Research Cancer Centers Consortium Annual Meeting. In addition, NextCure appointed Dr. Segal to its Scientific Advisory Board (SAB). Dr. Segal and NextCure shared new data from a nonclinical research study, which was led by Dr. Segal, in a poster presented at the 24th Translational Research Cancer Centers Consortium (TRCCC) Annual Meeting. The poster, titled “Targeting LAIR-1 abrogates neutrophil-mediated suppression of T cell responses in ovarian cancer microenvironment,” details nonclinical modeling of immune cell interactions in the ovarian cancer tumor microenvironment (TME). Dr. Segal and his research team previously published work showing that neutrophils acquire complement-dependent suppressor function in the TME characterized by inhibition of stimulated T cell proliferation and activation. In the current study, researchers showed that NC410, a fusion protein of LAIR-2, prevented neutrophil-driven non-responsiveness of T cells. These data support further investigation into specific roles of LAIR-1 engagement on neutrophils and T cells in the TME and mechanisms by which NC410 can rescue T cell responsiveness. “Dr. Segal and members of his lab have applied their expertise of the innate immune system to delineate mechanisms by which neutrophils suppress T cells in the TME and contributes to overall immunosuppression,” said Sol Langermann, Ph.D., NextCure’s chief scientific officer. “The new research study from Dr. Segal and his team demonstrated that, in the TME, NC410 blocks neutrophil-mediated T cell suppression. This novel find...