Neurocrine Biosciences Presents New Post-Hoc Analysis of ONGENTYS® (opicapone) Capsules Effect on COMT Activity at the 2022 MDS International Congress

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[{"type":"text","content":"SAN DIEGO, Sept. 15, 2022 /PRNewswire/ -- Neurocrine Biosciences, Inc. (Nasdaq: NBIX) today will present data on the effects of ONGENTYS® (opicapone) capsules on soluble-catechol-O-methyltransferase (S-COMT) enzyme inhibition. These data (abstract #1025) are being shared at the MDS International Congress of Parkinson's Disease and Movement Disorders® September 15-18 in Madrid, Spain.\n\n \n \n \n \n \n \n\n \n\"These data demonstrate that COMT inhibition shown by opicapone leads to more consistent daily levodopa exposure, which continues to be a challenge and goal in treating Parkinson's disease,\" said Eiry W. Roberts, MD, Chief Medical Officer at Neurocrine Biosciences. \"Adding a once-daily dose of opicapone 50 mg to levodopa/carbidopa resulted in inhibition of S-COMT activity and reduced fluctuations in L-dopa concentrations regardless of disease state, age, sex, ethnicity, or BMI.\"\nThe post-hoc analyses were conducted using data from 2 previous open-label Phase 1 studies of ONGENTYS, an approved once-daily adjunctive treatment to levodopa/carbidopa in patients with Parkinson's disease experiencing OFF time. Results of this post-hoc analysis showed that once-daily ONGENTYS 50 mg, when added to levodopa/carbidopa, decreased mean S-COMT activity by more than 80 percent in both patients with Parkinson's disease and healthy participants. Mean percentage reduction in S-COMT activity was 79–85 percent for all subgroups in both individual and pooled studies, although some subgroups had small participant numbers. ONGENTYS also reduced inter-patient variability in S-COMT activity by 86 percent from baseline.\nNeurocrine Biosciences will also present survey results (abstract #993) on the continuing educational needs of U.S. clinicians managing OFF episodes in Parkinson's disease, demonstrating the variability in approach to managing OFF episodes and need for relevant Continuing Medical Education approaches.\nA full list of abstracts being presented by Neurocrine Biosciences at MDS International Congress of Parkinson's Disease and Movement Disorders® is available on the meeting website.\nAbout ONGENTYS® (opicapone) Capsules ONGENTYS is a once-daily, oral, peripheral, selective, and reversible catechol-O-methyltransferase (COMT) inhibitor approved by the U.S. Food and Drug Administration (FDA) in April 2020 as an add-on treatment to l...

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