Neurocrine Biosciences Presents Data at MDS International Congress of Parkinson's Disease and Movement Disorders® Demonstrating Comparable Improvement Over Time in Tardive Dyskinesia Severity and Impact Following Treatment With INGREZZA® (valbenazine)...

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[{"type":"text","content":"Neurocrine Biosciences Presents Data at MDS International Congress of Parkinson's Disease and Movement Disorders® Demonstrating Comparable Improvement Over Time in Tardive Dyskinesia Severity and Impact Following Treatment With INGREZZA® (valbenazine) Capsules \n \n\nSAN DIEGO, Aug. 29, 2023 /PRNewswire/ -- Neurocrine Biosciences, Inc. (Nasdaq: NBIX) today presented findings from a data analysis of KINECT®-4 demonstrating a comparable pattern of improvement over time of clinician-rated tardive dyskinesia (TD) severity and awareness/distress as measured by the Abnormal Involuntary Movement Scale (AIMS) and patient-reported TD impact as measured by the Trajectories of Tardive Dyskinesia Impact Scale (TDIS). The data (Poster #657) was presented at the MDS International Congress of Parkinson's Disease and Movement Disorders® in Copenhagen, Denmark.\n\n \n \n \n \n \n \n\n \nThe data analysis evaluated the use of INGREZZA for the treatment of TD among all 167 patients with either schizophrenia or mood disorders enrolled over the course of the Phase 3, open-label, long-term study. On average, the analysis suggested that clinician-rated TD severity as measured by AIMS and patient-reported assessment of the physical, social and emotional impact of TD as measured by TDIS decreased with one-capsule, once-daily INGREZZA treatment over the course of the 48-week study. Researchers concluded that the use of AIMS and TDIS in evaluating symptom improvement during treatment may give a more complementary understanding regarding the patient's TD experience.\n\"The use of AIMS and TDIS provides a more complete perspective on the patient's TD experience,\" said Eiry W. Roberts, M.D., Chief Medical Officer at Neurocrine Biosciences. \"While AIMS is helpful to assess TD severity as perceived by the healthcare provider and to follow the severity of TD over time, TDIS enables us to assess the physical, social and emotional impact of these involuntary movements from the patient perspective. The insight gained from these data also supports the efficacy of treatment with INGREZZA in reducing both HCP-perceived severity and patient-reported impact of TD.\"\nThe study showed that though AIMS and TDIS measure unique aspects of TD, TDIS demonstrated a comparable pattern of improvement to the AIMS total score, TD severity as measured by AIMS item 8 (AIMS8), inc...

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