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Neumora Therapeutics Announces NMRA-266 IND Clearance and Initiation of Phase 1 Clinical Study
NMRA-266 is a highly selective positive allosteric modulator of the M4 muscarinic receptor, a clinically validated target for the treatment of schizophrenia
About this update from Neumora Therapeutics, Inc.
[{"type":"text","content":"NMRA-266 is a highly selective positive allosteric modulator of the M4 muscarinic receptor, a clinically validated target for the treatment of schizophrenia\nWATERTOWN, Mass., Nov. 27, 2023 (GLOBE NEWSWIRE) -- Neumora Therapeutics, Inc. (Neumora), a clinical-stage biopharmaceutical company redefining neuroscience drug development, today announced the initiation of a Phase 1 single ascending dose / multiple ascending dose study evaluating NMRA-266 in healthy adult participants. NMRA-266 is a highly selective positive allosteric modulator of the M4 muscarinic receptor that Neumora is developing as a treatment for schizophrenia and other neuropsychiatric disorders. “The initiation of this Phase 1 study is an important step in the development of NMRA-266. In pre-clinical studies NMRA-266 demonstrated a favorable pharmacologic profile that includes high potency and selectivity for the M4 receptor subtype, meriting its advancement into the clinic,” said Robert Lenz, M.D. Ph.D., executive vice president and head of research and development, Neumora. “With its pre-clinical profile and clinical validation of the M4 muscarinic receptor class in treating schizophrenia, we believe that NMRA-266 has strong potential as a treatment for neuropsychiatric disorders.” Neumora believes that as a selective M4 receptor-positive allosteric modulator, NMRA-266 has the potential to deliver antipsychotic efficacy, while minimizing the side effects associated with current antipsychotics and other non-selective muscarinic agonists. “Muscarinic receptor-targeting compounds have demonstrated robust activity in multiple clinical trials, reinforcing the potential of this class of medicines as an approach to treating schizophrenia and other neuropsychiatric disorders,” said John H. Krystal, M.D., Robert L. McNeil, Jr. Professor of Translational Research and Professor of Psychiatry, of Neuroscience, and Psychology, and chair of the Yale Department of Psychiatry at Yale School of Medicine. “Schizophrenia is a serious and debilitating disorder. Limitations in the effectiveness of existing treatments result in significant unmet medical need. Pharmacologic treatment is an integral part of a comprehensive treatment plan, and finding the right treatment option for each patient is vitally important. As such, it’s encouraging to see the development of multiple products...