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Neumora Therapeutics Announces Initiation of Phase 1b Study of NMRA-511 for Treatment of Alzheimer’s Disease Agitation
NMRA-511 is a highly potent and selective, best-in-class, antagonist of the vasopressin 1a receptor, which is known to play a role in regulation of
About this update from Neumora Therapeutics, Inc.
[{"type":"text","content":"NMRA-511 is a highly potent and selective, best-in-class, antagonist of the vasopressin 1a receptor, which is known to play a role in regulation of aggression, stress and anxiety response NMRA-511 was generally well-tolerated at all dose levels in Phase 1 single ascending dose / multiple ascending dose study, with no serious adverse events reported to date Alzheimer’s disease agitation is associated with increased morbidity and mortality and creates significant burden for patients and caregivers WATERTOWN, Mass., June 20, 2024 (GLOBE NEWSWIRE) -- Neumora Therapeutics, Inc. (Neumora), a clinical-stage biopharmaceutical company with a therapeutics pipeline consisting of seven clinical and pre-clinical brain disease programs, today announced the initiation of a Phase 1b study evaluating NMRA-511 for the treatment of agitation associated with dementia due to Alzheimer’s disease (AD). NMRA-511 is an oral, highly potent and selective antagonist of the vasopressin 1a receptor (V1aR) and is highly brain penetrant. Modulation of the V1aR is known to play a role in the regulation of aggression, stress and anxiety responses. “We believe there is a strong rationale to evaluate the potential benefits of NMRA-511 for the treatment of agitation associated with dementia due to AD given the preclinical and clinical data supporting the role that the V1aR plays in regulating key agitation-related processes in the brain,” said Robert Lenz, M.D., Ph.D., executive vice president and head of research and development, Neumora. “Millions of people in the U.S. are impacted by AD, and agitation is one of the most disruptive and burdensome symptoms for individuals and their families as it is associated with greater caregiver stress, increased morbidity and mortality, and earlier placement in long-term care facilities. Despite the significant impact of agitation in AD, there is currently only one approved product available, which carries a black-box warning for mortality in elderly people. We believe that patients deserve added treatment options and are eager to further elucidate the potential of NMRA-511 in this indication.” The Phase 1b study will investigate NMRA-511 initially in healthy elderly adult participants and then people with agitation associated with dementia due to AD. Part A of the Phase 1b study will be a randomized, double-blind, placebo-co...