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Nektar Therapeutics Presents Data for Rezpegaldesleukin (LY3471851) in Patients with Atopic Dermatitis and Psoriasis from Two Separate Clinical Studies at 2022 European Academy of Dermatology (EADV) Congress
SAN FRANCISCO, Sept. 7, 2022 /PRNewswire/ -- Nektar Therapeutics (Nasdaq: NKTR) today announced data presentations from two Phase 1b, proof-of-concept studies
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[{"type":"text","content":"SAN FRANCISCO, Sept. 7, 2022 /PRNewswire/ -- Nektar Therapeutics (Nasdaq: NKTR) today announced data presentations from two Phase 1b, proof-of-concept studies of rezpegaldesleukin (also known as LY3471851 or NKTR-358) in patients with atopic dermatitis (AD) and plaque psoriasis at the 2022 European Academy of Dermatology and Venereology (EADV) Congress.\n\n \n \n \n \n \n \n\n \nRezpegaldesleukin is a novel, first-in-class selective regulatory T-cell (Treg) inducing IL-2 conjugate in development to treat autoimmune and inflammatory conditions. It is designed to target the immune system imbalance that results from increased levels of inflammatory T cells and reduced numbers and impaired function of regulatory T cells (Tregs). Decreased Treg numbers or impaired immunosuppressive function are known to contribute to the pathogenesis of multiple autoimmune and inflammatory diseases, including atopic dermatitis and psoriasis.1\nData are being presented at EADV from both a Phase 1b double-blind, randomized, placebo-controlled multiple-dose study evaluating the safety, tolerability, and pharmacokinetics of rezpegaldesleukin in patients with moderate-to-severe AD, as well as a Phase 1b double-blind, placebo-controlled study evaluating rezpegaldesleukin in patients with plaque psoriasis who are candidates for systemic therapy or phototherapy. Both studies were sponsored by Eli Lilly and Company.\n\"The results continue to demonstrate the potential of rezpegaldesleukin to emerge as a truly differentiated therapy for patients with serious inflammatory conditions,\" said Brian L. Kotzin, M.D., Chief Medical Officer of Nektar. \"In atopic dermatitis, dose-dependent improvements in key efficacy measures were observed for an additional 36 weeks following the 12-week treatment period. These proof-of-concept data show rezpegaldesleukin's ability to stimulate Tregs to target an immune system imbalance resulting in an improvement of disease activity in patients.\"\nKey details and takeaways from the presentations are as follows:\nAbstract P1242: \"Efficacy and Safety of a Selective Regulatory T-Cell Inducing IL-2 Conjugate (LY3471851) in the Treatment of Atopic Dermatitis: A Phase 1 Randomised Study\"\nThe IL-2 conjugate Treg stimulator, LY3471851, had a safety profile at the doses studied that supports further clinical development of LY3471851 in ...