Health
In Treating Measles Infection, NV-387 Showed Strong Antiviral Activity, and Significantly, Protected Lungs from Damage, Describes NanoViricides
SHELTON, CONNECTICUT / ACCESS Newswire / October 22, 2025 / NanoViricides, Inc., a publicly traded company (NYSE Amer:NNVC) (the "Company"), announced that its clinical lead drug NV-387 has shown strong activity against the Measles virus in cell culture ...
About this update from Nanoviricides, Inc.
[{"type":"text","content":"SHELTON, CONNECTICUT / ACCESS Newswire / October 22, 2025 / NanoViricides, Inc., a publicly traded company (NYSE Amer:NNVC) (the "Company"), announced that its clinical lead drug NV-387 has shown strong activity against the Measles virus in cell culture studies as well as in a humanized animal model. Additionally, NV-387 treatment led to protection of lungs which is very important for keeping severely ill patients alive in late-stage viral infections. Currently, there is no approved drug for treating Measles.","length":524,"tagName":"p"},{"type":"text","content":"Firstly, NV-387 was found to have direct antiviral effects against Measles virus in standard cell culture-based testing that measured increase in the extent of surviving infected cells upon treatment with the drug (i.e. "CPE" or Cytopathic Effects Assay).","length":265,"tagName":"p"},{"type":"text","content":"Additionally, in a lethal Measles infection humanized animal model, NV-387 treatment led to a substantial increase in the number of survival days, to 17 days in NV-387-treated animals, from only 7.4 days in untreated animals, an increase of 130%, in a lethal lung infection of humanized mice by Measles virus1, as previously reported.","length":334,"tagName":"p"},{"type":"text","content":"The increased survival correlated with several improvements in the animal health indicating control of viral infection:","length":119,"tagName":"p"},{"type":"list","items":[{"val":[{"type":"text","content":"Slow disease progression, and mild to moderate levels of lung damage as observed in microscopic histopathology.","length":111,"tagName":"p"}]},{"val":[{"type":"text","content":"Protection of lungs was also evident from the significant reduction in the level of lung plaques (damage to lung tissue) compared to untreated cases.","length":149,"tagName":"p"}]},{"val":[{"type":"text","content":"Reduction in the level of lung-damaging lymphocytes and neutrophils attracted into the lungs (i.e. infiltration).","length":113,"tagName":"p"}]}],"tagName":"ul","bulletedList":true,"length":373,"olType":false},{"type":"text","content":"These observations indicated that NV-387 treatment led to beneficial effects that protected lungs as well as reduced overall systemic infection.","length":144,"tagName":"p"},{"type":"text","content":"We have thus found that NV-387 has dual bene...