Myriad Genetics Announces Publication of a Meta-Analysis Demonstrating the Clinical Utility of the GeneSight® Psychotropic Test in People with Major Depressive Disorder

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[{"type":"text","content":"New Article Published Online in the Journal Pharmacogenomics\nSALT LAKE CITY, April 20, 2020 (GLOBE NEWSWIRE) -- Myriad Genetics, Inc. (NASDAQ: MYGN, “Myriad” or the “Company”), a global leader in molecular diagnostics and precision medicine, today announced the publication of a meta-analysis of four clinical trials demonstrating that the GeneSight® Psychotropic test significantly improves clinical outcomes among patients with major depressive disorder (MDD). The article titled, “The Clinical Utility of Combinatorial Pharmacogenetic Testing for Patients with Depression: A Meta-Analysis,” appeared online in the journal Pharmacogenomics.\n “Many commercial insurers and health technology assessors in the United States and internationally consider meta-analyses the highest level of clinical evidence for the treatment of depression,” said Bryan Dechairo, Ph.D., executive vice president of Clinical Development at Myriad. “Our meta-analysis further demonstrates the consistent clinical utility of the GeneSight Psychotropic test across multiple cohorts of patients with depression. Importantly, the data showed that when clinicians used the GeneSight test to guide clinical care their patients achieved statistically significantly better remission, response and symptom improvement.” The analysis included data from four prospective, controlled trials that evaluated the clinical utility of the GeneSight test in 1,556 people with MDD and who had at least one prior antidepressant medication failure. All four studies evaluated remission, response, and symptom improvement outcomes using the 17-item Hamilton Depression Rating Scale (HAM-D17) among patients whose medication selection was informed by the GeneSight test results (guided care) compared to unguided care (treatment as usual). The results demonstrate that outcomes were significantly improved for patients whose care was guided by the GeneSight test compared to unguided care. Overall remission improved 49 percent (p=.001), response improved by 40 percent and (p","length":2738,"tagName":"div"}]

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