Business
Mustang Bio Provides CAR T Cell Therapy Portfolio Updates and 2023 Anticipated Milestones
MB-106 clinical trial under Mustang’s IND continues to enroll patients Additional IND filing and published research expected in 2023 across portfolio
About this update from Mustang Bio, Inc.
[{"type":"text","content":"MB-106 clinical trial under Mustang’s IND continues to enroll patients Additional IND filing and published research expected in 2023 across portfolio WORCESTER, Mass., Dec. 19, 2022 (GLOBE NEWSWIRE) -- Mustang Bio, Inc. (“Mustang”) (Nasdaq: MBIO), a clinical-stage biopharmaceutical company focused on translating today’s medical breakthroughs in cell and gene therapies into potential cures for hematologic cancers, solid tumors and rare genetic diseases, today announced recent CAR T cell therapy portfolio updates and provided anticipated milestones for 2023. Manuel Litchman, M.D., President and Chief Executive Officer of Mustang, said, “In 2022, Mustang successfully advanced our CAR T cell therapy portfolio which has laid the foundation for us to achieve multiple milestones in the coming year. Our lead clinical candidate, MB-106, a first-in-class CD20-targeted, autologous CAR T cell therapy for the treatment of relapsed or refractory B-cell non-Hodgkin lymphomas (“B-NHL”) and chronic lymphocytic leukemia (“CLL”), continues to progress in our multicenter Phase 1/2 clinical trial. We’re pleased to report that Mustang has met its accrual target for the year for that trial and has manufactured product for all enrolled patients. We look forward to providing first safety and efficacy data in 2023. Additionally, data from the initial ongoing Phase 1/2 clinical trial taking place at Fred Hutchinson Cancer Center (“Fred Hutch”) continue to exhibit high efficacy and a favorable safety profile compared to currently approved autologous CAR Ts. In particular, while other cell therapies in development have struggled to show durability of response, we reported in October that twelve of 28 patients enrolled had experienced complete remission (CR) for more than 12 months (10 ongoing), four patients had experienced CR for more than 2 years (all ongoing), and the first patient enrolled was in sustained CR at 33 months.” “In 2023, we anticipate filing an Investigational New Drug application (“IND”) for our combination therapy MB-109 to treat glioblastoma (“GBM”). Additionally, we continue to collaborate with the Mayo Clinic to progress our exclusively licensed novel in vivo CAR T technology platform and anticipate the publication of proof-of-concept research in a murine tumor model. We’re looking forward to another productive year across our CAR T th...