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Mustang Bio Announces MB-106 CD20-Targeted CAR T Data Selected for Presentation at 63rd American Society of Hematology (ASH) Annual Meeting
Key opinion leader webinar on Thursday, December 16, 2021, at 2:30 p.m. ET WORCESTER, Mass., Nov. 04, 2021 (GLOBE NEWSWIRE) -- Mustang Bio, Inc. (“Mustang”)
About this update from Mustang Bio, Inc.
[{"type":"text","content":"Key opinion leader webinar on Thursday, December 16, 2021, at 2:30 p.m. ET\nWORCESTER, Mass., Nov. 04, 2021 (GLOBE NEWSWIRE) -- Mustang Bio, Inc. (“Mustang”) (NASDAQ: MBIO), a clinical-stage biopharmaceutical company focused on translating today’s medical breakthroughs in cell and gene therapies into potential cures for hematologic cancers, solid tumors and rare genetic diseases, today announced that interim Phase 1/2 data on MB-106, a CD20-targeted, autologous CAR T cell therapy for patients with relapsed or refractory B-cell non-Hodgkin lymphomas (“NHL”) and chronic lymphocytic leukemia (“CLL”), have been selected for a poster presentation at the 63rd American Society of Hematology Annual Meeting (“ASH2021”), which is being held from December 11-14, 2021. MB-106 is being developed in a collaboration between Mustang and Fred Hutchinson Cancer Research Center (“Fred Hutch”). The abstract posted today on the ASH2021 website reported on 16 patients [12 follicular lymphoma (“FL”), 2 mantle cell lymphoma (“MCL”), 1 CLL and 1 diffuse large B-cell lymphoma (“DLBCL”)] treated following a major cell manufacturing process modification. CAR T cells are administered at one of 4 dose levels (“DL”): DL1: 3.3x105, DL2: 1x106, DL3: 3.3x106, DL4: 1x107 CAR T cells/kg. All DLs were reached, with no dose-limiting toxicities observed to date. The overall response rate (“ORR”) was 94% (15/16) with a complete response (“CR”) rate of 62% (10/16). In patients with FL (n=12), ORR was 92% (11/12) and CR rate was 75% (9/12). Among patients with FL who received DL 3 or 4, the CR rate was 86%. The patient with CLL had a PET-negative CR and undetectable measurable residual disease in peripheral blood and bone marrow by flow cytometry at a sensitivity of 10-4 (uMRD4) on day 28. The patient with DLBCL achieved a partial response (“PR”) on day 28, and a repeat PET on day ~90 showed deepening of the PR. Among patients who achieved a CR, only one patient with FL relapsed after 9 months. All other CRs are ongoing (range: 3-18 months). CAR T persistence was lost at day 95 in one patient who had progression and proceeded to other anti-lymphoma treatment; 2 other patients lost CAR T engraftment by day 181 and 201 with B-cell recovery. All other patients continue to have detectable CAR T cells as of last follow-up (maximum of 13 months post-infusion). Among the 16 to...