Business
Moleculin Announces Publication of Data from Successful European Phase 1 Trial Evaluating Annamycin as Single Agent Treatment of Relapsed or Refractory Acute Myeloid Leukemia (AML)
Data published in peer-reviewed British Journal of Cancer Research No evidence of cardiotoxicity in any subject treated in this study, including up to 16
About this update from Moleculin Biotech, Inc.
[{"type":"text","content":"Data published in peer-reviewed British Journal of Cancer Research\nNo evidence of cardiotoxicity in any subject treated in this study, including up to 16 subjects whose cumulative anthracycline dose (Annamycin included) exceeded the lifetime cumulative doxorubicin (or equivalent) dose of > 450 mg/m2 \nAfter experiencing an 80%/60% ORR/CRi rates in last single agent cohort, Annamycin is currently being evaluated in a Phase 1b/2 study in combination with Cytarabine for the treatment of AML\nHOUSTON, July 13, 2023 /PRNewswire/ -- Moleculin Biotech, Inc., (Nasdaq: MBRX) (Moleculin or the Company), a clinical stage pharmaceutical company with a broad portfolio of drug candidates targeting hard-to-treat tumors and viruses, today announced the publication of data from its completed MB-105 European Phase 1 clinical trial assessing the safety and efficacy of Annamycin as a single agent for the treatment of adults with relapsed or refractory AML. The manuscript titled, \"Results of a Phase 1 Study of Liposomal Annamycin for the Treatment of Relapsed or Refractory AML Patients After Induction Therapy,\" was published in the peer-reviewed British Journal of Cancer Research.\n\n \n \n \n \n \n \n\n \nThe authors of the published manuscript include Dr. Wolfram Dempke (Moleculin's European Chief Medical Officer), Dr. John Paul Waymack (Moleculin's Senior Chief Medical Officer) and Dr. Waldemar Priebe (Moleculin's Chair - Scientific Advisory Board), as well as Polish investigators from the MB-105 trial.\n\"We are pleased to have the data from our successful MB-105 study published in this prestigious journal,\" commented Walter Klemp, Chairman and CEO of Moleculin. \"This early data provided an important foundation for our AML program and was informative for guiding our clinical development strategy for Annamycin in combination with Cytarabine for the treatment of AML. We continue to be very optimistic about Annamycin's potential to provide a non-cardiotoxic treatment option for patients.\"\nMB-105 is the Company's completed multicenter, open-label, dose-escalation study which was conducted to determine the maximal tolerated dose (MTD) and recommended Phase 2 dose (RP2D) of Annamycin as a single agent for the treatment of patients with AML after induction therapy. A total of 20 subjects with the age range of 24-76 years with a median age of 64....