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MIRA Pharmaceuticals' Ketamir-2 Shows 60% Greater Efficacy Than FDA-Approved Gabapentin in Reversing Chemotherapy-Induced Neuropathic Pain
Promising Preclinical Results Position Ketamir-2 as a Potential Breakthrough Therapy That Surpasses Current Treatments, With Results to Be Presented at the
About this update from Mira Pharmaceuticals, Inc.
[{"type":"text","content":"Promising Preclinical Results Position Ketamir-2 as a Potential Breakthrough Therapy That Surpasses Current Treatments, With Results to Be Presented at the Pain Therapeutics Summit in BostonMIAMI, FL / ACCESSWIRE / October 28, 2024 / MIRA Pharmaceuticals, Inc. (NASDAQ:MIRA), a leading pre-clinical-stage pharmaceutical development company, announces compelling new preclinical findings showing that Ketamir-2, a novel oral ketamine analog, achieves 60% greater efficacy than the FDA-approved neuropathic pain treatment gabapentin in reducing chemotherapy-induced pain. These results build on earlier successes across various pain models, further validating Ketamir-2's potential to set a new standard in pain management.Study Overview and ResultsThe study used the paclitaxel (PTX) model, where neuropathic pain was induced in mice through the administration of PTX, a common chemotherapy drug. While effective in treating cancer, PTX often causes nerve damage, leading to chemotherapy-induced neuropathy characterized by pain, numbness, and tingling. To assess Ketamir-2's efficacy, mice received PTX every other day for four doses, and pain sensitivity was measured using the Von Frey filament (VFF) test. On Day 9, at the optimal dose of 300 mg/kg, Ketamir-2 led to near-complete normalization of pain sensitivity, outperforming FDA-approved gabapentin by 60%, which provided only moderate relief.The company will present these findings, along with data from previous studies, at the upcoming Pain Therapeutics Summit in Boston on October 28-29, 2024, to showcase Ketamir-2's therapeutic potential to the medical community. This presentation emphasizes MIRA's commitment to sharing its data with the broader scientific community and engaging with key opinion leaders to discuss the significance of these findings. Sharing these results with leading experts will be crucial in advancing the understanding of Ketamir-2's potential as a groundbreaking treatment.Potential for Breakthrough Therapy, Fast track and Priority ReviewThe promising results from this study could pave the way for Ketamir-2 to receive FDA breakthrough therapy designation, fast track, and/or priority review as an effective treatment for rare forms of cancer-related neuropathic pain, such as that associated with Multiple Myeloma. This rare cancer affects plasma cells in the bone marrow, lead...