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Mineralys Therapeutics Presents Positive Lorundrostat Results from the Phase 2 Target-HTN Trial at ACC.23/WCC
Lorundrostat demonstrated clinically meaningful blood pressure reduction in individuals with uncontrolled hypertension Obesity was predictive of an enhanced
About this update from Mineralys Therapeutics, Inc.
[{"type":"text","content":"Lorundrostat demonstrated clinically meaningful blood pressure reduction in individuals with uncontrolled hypertension Obesity was predictive of an enhanced response to lorundrostat with placebo-adjusted systolic BP reduction of 16.7 mmHg with 50mg once-daily dosing Additional clinical trial expected to begin in first half of 2023 RADNOR, Pa., March 04, 2023 (GLOBE NEWSWIRE) -- Mineralys Therapeutics, Inc. (Nasdaq: MLYS), a clinical-stage biopharmaceutical company focused on developing medicines to target diseases driven by abnormally elevated aldosterone, today announced positive data from the Target-HTN Phase 2 study that demonstrated clinically meaningful blood pressure reduction with once-daily dosing of lorundrostat at the American College of Cardiology’s 72nd Annual Scientific Session together with the World Congress of Cardiology (ACC.23/WCC) going on now in New Orleans, LA. In a pre-specified analysis, hypertensive subjects with a BMI ≥30 kg/m2, demonstrated a statistically significant reduction of placebo-adjusted change in systolic blood pressure (BP) of 16.7 mmHg (p=0.002) with 50mg QD and a reduction of 12.3 mmHg (p=0.030) with 100 mg QD in Part 1 of the study. “We continue to be excited by the compelling data from our Target-HTN trial. As detailed in the poster presentation at ACC.23/WCC today, the latest subgroup analysis of obese patients further supports our hypothesis of the linkage between obesity, aldosterone and hypertension,” stated Jon Congleton, Chief Executive Officer of Mineralys. “The prevalence of uncontrolled hypertension continues to grow, and with the rate of obesity rapidly rising in tandem, these data underscore our confidence that targeting the underlying cause of hypertension, abnormal aldosterone biology, has the potential to position lorundrostat earlier in the treatment paradigm.” The data from this sub-analysis of the Phase 2 study were presented in a moderated poster titled, “Highly Effective Blood Pressure Lowering with lorundrostat, a New Aldosterone Synthase Inhibitor, in Individuals with Obesity and RAAS Dysregulation” at the ACC.23/WCC. The poster is available on the Company’s website here. “Current hypertension treatments were developed and introduced several decades ago, when the incidence of obesity was below 20 percent and abnormal aldosterone production affected less than 10 perce...