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MiMedx Concludes Enrollment for Phase 2B Study of Osteoarthritis (OA) of the Knee
Research Advances Understanding of Amniotic Tissue as Potential Unique Treatment for Painful Chronic Condition that Affects 242 Million People Globally
About this update from Mimedx Group, Inc
[{"type":"text","content":"Research Advances Understanding of Amniotic Tissue as Potential Unique Treatment for Painful Chronic Condition that Affects 242 Million People Globally\n MARIETTA, Ga., Sept. 21, 2020 (GLOBE NEWSWIRE) -- MiMedx Group, Inc. (OTC PINK: MDXG) (“MiMedx” or “the Company”), an industry leader in advanced wound care and a therapeutic biologics company, announced the conclusion of enrollment into its Phase 2B study of its micronized injectable amniotic tissue product in patients with osteoarthritis (OA) of the knee (KOA). “Osteoarthritis is by far the most common joint disease – millions of adults experience pain and decreased quality of life every day because of joint destruction caused by osteoarthritis,” said Alfred Gellhorn, MD, Associate Professor of Clinical Rehabilitation and Director of Sports Medicine, Weill Cornell Medical Center. “Although knee replacement is an option for those with advanced knee arthritis, this should be reserved for end-stage disease; it is extremely expensive and carries significant potential risks. We are in desperate need of better conservative options to treat those with mild-to-moderate knee arthritis. Current treatments, including oral anti-inflammatory medications, cortisone injections, and hyaluronic acid injections, are very limited in the amount of relief they provide. Furthermore, anti-inflammatories have negative cardiovascular effects and injected steroids cause further joint degeneration. In my practice, patients are frustrated with these limited options and very interested in novel approaches that provide safe and long-lasting pain reduction. I believe this Phase 2B clinical trial is critically important to inform the potential for MiMedx’s amniotic membrane-based technology to fill this treatment void.” The OA Clinical Trial is the first randomized clinical study of a micronized dehydrated Human Amnion/Chorion Membrane (mdHACM) Injection in the Treatment of KOA. A previously published retrospective study by Dr. Gellhorn provided initial evidence of pain reduction and functional improvement in a cohort of 40 patients with chronic tendinopathy and arthropathy. The subsequent publication of an observational study by Kris Alden, M.D., Ph.D., Orthopaedic Surgeon, Hinsdale Orthopaedics, of 100 knee injections in 82 KOA patients provided further evidence that mdHACM injections reduced pain and imp...